Relationship between Antenatal Maternal Neutrophil-to-Lymphocyte Ratio and Early Onset Neonatal Sepsis in Preterm Neonates

Thai Journal of Obstetrics and Gynaecology

article

Thitiphan Chayawongrungreung¹  Jiraporn Luengmettakul¹  Aungsumalin Srilar¹ 

[1] Department of Obstetrics and Gynecology, Chareonkrung Pracharak Hospital, Medical Service Department, Bangkok Metropolitan Administration

关键词: Preterm neonates;    early onset neonatal sepsis;    neutrophil to lymphocyte ratio;   

DOI  :  10.14456/tjog.2020.13

学科分类：社会科学、人文和艺术（综合）

来源: The Royal Thai College of Obstetricians and Gynaecologists

【 摘 要 】

Objective: To determine the relationship between maternal neutrophil to lymphocyte ratio (NLR) and early onset neonatal sepsis (EONS) in preterm neonates. Materials and Methods: Between 2012 to 2016, a total of 485 cases of preterm delivery were retrospectively reviewed. Study group consisted of 97 neonates diagnosed with EONS and other 388 without EONS were randomly selected as a comparison group (1:4 ratio). Data were extracted from medical records, including baseline characteristics, obstetric and delivery data. Maternal NLR was calculated from laboratory results within 72 hours prior to delivery. Results: Neonates with EONS were significantly more likely to deliver at 5 significantly increased the risk of EONS (26.8% vs. 16.4%, p=0.007). Logistic regression analysis showed that delivery at 5 independently increased the risk of EONS in those delivered at 34 weeks (adjusted OR 6.1, 95% CI 1.8-20.3). Conclusion: Maternal NLR was significantly associated with EONS in preterm neonates, especially those delivered at <34 weeks.

【 授权许可】

CC BY-NC-ND