Predictive Factors of Histological Response after Preoperative Concomitant Radiochemotherapy in Middle and Low Rectal Cancer

Asian Pacific Journal of Cancer Care

article

Asmae Ouabdelmoumen  Ali Sbai¹  Fouad Elmejjatti¹  Zohour Bourhaleb²  Naima Abda³  Loubna Mezouar¹ 

[1] Departement of Radiotherapy, Center of oncology HassanII, University Hospital MOHAMED VI, km 8 route Jerada;Departement of Radiotherapy, University Hospital IBN ROCHD, quartier des Hôpitaux;Laboratory of Epidemiology and Public Health, Medical Faculty of Oujda, Mohammed Premier University

关键词: Rectal cancer;    adenocarcinoma;    neoadjuvant radiochemotherapy;    histologic response;    predictive factors;   

DOI  :  10.31557/apjcc.2018.3.3.65

学科分类：内科医学

来源: West Asia Organization for Cancer Prevention

【 摘 要 】

Objective: The aim of our study was to identify potential predictive factors beyond pathologic response after neoadjuvant radiochemotherapy.Patients and Methods: Between January 2009 and December 2014, 40 patients with rectal carcinoma were included in the study. The treatment consisted of radiation ranging between 39 and 50.4 Gy associated with a concomitant chemotherapy with capecitabine. The correlation between histological response (complete response and downstaging) and potential predictive factors were investigated.Results: Complete response was 15% (06 patients), tumor regression of 32.5% (13 patients), and the absence of tumor response of 52.5% (21 patients). In univariate analysis, the circumferential extension of the tumor was significantly associated with tumor downstaging (p = 0.007) and complete tumor response (p = 0.001). However, the delay between the RCT and the surgery was a significant predictor for downstaging (p = 0.02).Conclusion: the parietal circumferential extension was a potential predictor of pathologic complete response (PCR) and downstaging after neoadjuvant chemoradiation. The time between the radiochemotherapy and the surgery was a significant predictor for downstaging. Delaying surgery beyond 8 weeks seems to result in the highest probability of PCR.

【 授权许可】

CC BY