Yoghurt kedelai hitam (black soyghurt) dapat menurunkan kadar LDL tikus hiperkolesterolemiaDOI : 10.21927/ijnd.2015.3(1).1-9 | Abstract views : 1125 times

Jurnal Gizi dan Dietetik Indonesia

article

Slamet Riyanto¹  Hesti Muwarni R² 

[1] Balai Penelitian GAKI Magelang. Balitbang Kemenkes;Program Studi Ilmu Gizi Fakultas Kedokteran Universitas Diponegoro

关键词: black soyghurt;    LDL/HDL ratio;    hypercholesterolemic;    rasio LDL/HDL;    hiperkolesterolemia;   

DOI  :  10.21927/ijnd.2015.3(1).1-9

来源: Alma Ata University Press

【 摘 要 】

Background : Hypercholesterolemia is a main risk factor of cardiovascular disease that remains the higher cause of deaths in the world. Black soy bean containing protein, fiber, vitamin, isoflavon, and flavonoid can decrease serum cholesterol level. Yoghurt contains lactic acid bacteria that decrease total and LDL cholesterol, triglyceride, and increase the HDL cholesterol. Processing of black soy bean into black soyghurt can increase its isoflavon’s activity by forming aglicone, which has higher activity to decrease cholesterol. Objectives : To know the effect of black soyghurt feeding to LDL, HDL, and HDL ratio of hypercholesterolemic rats. Methods : This research was true-experimental using post test only with control group design. Subjects were 20 male Sprague dawley rats, 2 months old, inducted hypercholesterolemia, given black soyghurt diet using 2 mL, 3 mL, and 4 mL dosage for 21 days. Serum lipid profile were measured by CHOD-PAP and GPO-PAP methods respectively. Normality of the data were tested by Shapiro Wilks test. Data were analyzed by paired t test and Anova continued by LSD test using computer program. Results : The study revealed that black soyghurt 4 mL/day decreased LDL (p=0.02) at the most significant level. The other doses did not significantly influence the levels of LDL (p>0.05 ). There was also no effect of black soyghurt feeding on serum HDL cholesterol levels (p=0.11) and the ratio of LDL /HDL (p=0.087). Conclusions : The feeding of black soyghurt at the dosage of 4 mL/day to hypercholesterolemic rats could decrease the serum LDL, but could decrease the ratio of LDL / HDL significantly.

【 授权许可】

Unknown