Optimum Mixture Designs for Binomial Two-Parameter Log-Logistic (LL2) Model with Mixture of Two Similar CompoundsOptimal design for log-logistic model (LL2)

Austrian Journal of Statistics

article

Pattaraporn Tusto¹  Montip Tiensuwan²  Manisha Pal³ 

[1] Department of Mathematics, Phranakhon Rajabhat University;Department of Mathematics, Faculty of Science, Mahidol University;Department of Statistics, University of Calcutta

关键词: dose-response experiment;    log-logistic (LL2) model;    mixture experiment;    parameterestimation;    D-optimality criterion;    Ds-optimality criterion.;   

DOI  :  10.17713/ajs.v49i1.850

学科分类：医学（综合）

来源: Austrian Statistical Society

【 摘 要 】

The paper investigates the class of two-parameter log-logistic dose-response bioassay models in the binomial set-up. The dose is defined by the potency adjusted mixing proportions of two similar compounds. The aim is to investigate the D- and Ds- optimal mixture designs for estimating the full set of parameters or only the potency for a best guess of the parameter values. An indication has been given for finding the optimal design for the estimation of the mixture at which the probability of success attains a given value.

【 授权许可】

CC BY