Establishment of an immune-related gene pair model to predict colon adenocarcinoma prognosis

BMC Cancer

Jihang Luo¹  Yi Huang¹  Yuju Bai¹  Yuanyan Wang¹  Ze Yang¹  Duo Chen¹  Wenjing Geng¹  Puyu Liu²  Leibo Wang³ 

[1] Cancer Hospital, Second Affiliated Hospital of Zunyi Medical University, 563000, Zunyi City, Guizhou Province, China;Department of Pathology, Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China;Department of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China;

关键词: Colon adenocarcinoma;    Immune-related gene pairs;    Prognosis;    TCGA;    GEO;   

DOI  :  10.1186/s12885-020-07532-7

来源: Springer

【 摘 要 】

BackgroundColon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported the correlation between the prognosis of COAD and the immune system. The current study aimed to develop a robust prognostic immune-related gene pair (IRGP) model to estimate the overall survival of patients with COAD.MethodsThe gene expression profiles and clinical information of patients with colon adenocarcinoma were obtained from the TCGA and GEO databases and were divided into training and validation cohorts. Immune genes were selected that showed a significant association with prognosis.ResultsAmong 1647 immune genes, a model with 17 IRGPs was built that was significantly associated with OS in the training cohort. In the training and validation datasets, the IRGP model divided patients into the high-risk group and low-risk group, and the prognosis of the high-risk group was significantly worse (P<0.001). Univariate and multivariate Cox proportional hazard analyses confirmed the feasibility of this model. Functional analysis confirmed that multiple tumor progression and stem cell growth-related pathways were upregulated in the high-risk groups. Regulatory T cells and macrophages M0 were significantly highly expressed in the high-risk group.ConclusionWe successfully constructed an IRGP model that can predict the prognosis of COAD, providing new insights into the treatment strategy of COAD.

【 授权许可】

CC BY