Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method

Journal of Neurodevelopmental Disorders

Thomas Vaessen¹  Zuzana Kasanova¹  Inez Myin-Germeys¹  Maude Schneider²  Ann Swillen³  Thérèse van Amelsvoort⁴  Wolfgang Viechtbauer⁴  Ulrich Reininghaus⁵  Esther D. A. van Duin⁶  Jacob A. S. Vorstman⁷  Jan Booij⁸  Claudia Vingerhoets⁸ 

[1] Center for Contextual Psychiatry, Department of Neurosciences, KU Leuven, Kapucijnenvoer 33 Bus 7001 (Blok H), 3000, Leuven, Belgium;Clinical Psychology Unit for Intellectual and Developmental Disabilities, Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont d’Arve 40, 1205, Geneva, Switzerland;Center for Contextual Psychiatry, Department of Neurosciences, KU Leuven, Kapucijnenvoer 33 Bus 7001 (Blok H), 3000, Leuven, Belgium;Department of Human Genetics, KU Leuven, Herestraat 49, 3000, Leuven, Belgium;Center for Human Genetics, Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium;Department of Psychiatry & Neuropsychology, Maastricht University, Minderbroedersberg 4-6, 6211 LK, Maastricht, The Netherlands;Department of Psychiatry & Neuropsychology, Maastricht University, Minderbroedersberg 4-6, 6211 LK, Maastricht, The Netherlands;Centre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, David Goldberg Centre, King’s College London, 18 De Crespigny Park, SE5 8AF, London, UK;Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany;Department of Psychiatry & Neuropsychology, Maastricht University, Minderbroedersberg 4-6, 6211 LK, Maastricht, The Netherlands;Institute for Interdisciplinary Studies, University of Amsterdam, PO Box 94224, Science Park 904, 1090 GE, Amsterdam, The Netherlands;Department of Psychiatry, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Burton Wing, M5G 1X8, Toronto, Ontario, Canada;Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, 686 Bay St., M5G 0A4, Toronto, Ontario, Canada;Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands;

关键词: Experience sampling method;    22q11.2 deletion syndrome;    Stress reactivity;    Positive affect;    Negative affect;    Momentary psychotic experiences;   

DOI  :  10.1186/s11689-020-09333-2

来源: Springer

【 摘 要 】

Background22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with an increased risk of psychiatric disorders. Vulnerability for psychopathology has been related to an increased reactivity to stress. Here, we examined affective states, perceived stress, affective and psychotic reactivity to various sources of environmental stress using the experience sampling method (ESM), a structured diary technique allowing repeated assessments in the context of daily life.MethodsAdults with 22q11DS (n = 31; age, 34.1 years) and matched healthy controls (HCs; n = 24; age, 39.9 years) were included. ESM was used to assess affective states, perceived stress, and stress reactivity. Data were analyzed using multilevel regression models.ResultsAdults with 22q11DS displayed overall higher levels of negative affect but comparable levels of positive affect compared to HCs. Higher levels of perceived stress were reported by individuals with 22q11DS. Comparable affective and psychotic reactivity in relation to all types of environmental stress was observed between the two groups.ConclusionThe results point toward higher levels of negative affect and differences in the perception of daily hassles in 22q11DS but no difference in affective or psychotic reactivity to stress. This study contributes to the growing literature regarding the impact of stress on the development of psychopathology in the 22q11DS population.

【 授权许可】

CC BY