Preoperative AminoIndex Cancer Screening (AICS) abnormalities predict postoperative recurrence in patients undergoing curative resection for non-small cell lung cancer

BMC Cancer

Jiro Okami¹  Tomohiro Maniwa¹  Toru Kimura¹  Masahiko Higashiyama²  Fumio Imamura³  Kentaro Hirohashi⁴  Ryohei Miyazaki⁴  Takashi Anayama⁴  Kazumasa Orihashi⁴  Hiroshi Yamamoto⁵  Shinya Kikuchi⁵ 

[1] Department of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan;Department of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan;Department of Thoracic Surgery, Higashiosaka City Medical Center, Higashiosaka, Osaka, Japan;Department of Medical Oncology, Osaka International Cancer Institute, Osaka, Japan;Division of Thoracic Surgery, Department of Surgery II, Kochi University School of Medicine, Kochi, Japan;Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., Yokohama, Kanagawa, Japan;

关键词: AICS;    AICS (lung);    Lung cancer;    Surgery;    Recurrence;    Prognosis;    Non-small cell lung cancer;   

DOI  :  10.1186/s12885-020-07575-w

来源: Springer

【 摘 要 】

BackgroundAminoIndex™ Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed of PFAA, the probability of lung cancer was categorized into AICS (lung) ranks A, B, and C in order of increasing risk. The aim of the present study was to investigate the relationship between the preoperative AICS (lung) rank and surgical outcomes in patients who underwent curative resection for non-small cell lung cancer (NSCLC).MethodsPreoperative blood samples were collected from 297 patients who underwent curative resection for NSCLC between 2006 and 2015. PFAA concentrations were measured. The relationship between the preoperative AICS (lung) rank and clinicopathological factors was examined. The effects of the preoperative AICS (lung) rank on postoperative outcomes were also analyzed.ResultsThe AICS (lung) rank was A in 93 patients (31.3%), B in 82 (27.6%), and C in 122 (41.1%). The AICS (lung) rank did not correlate with any clinicopathological factors, except for age. Based on follow-up data (median follow-up period of 6 years), postoperative recurrence was observed in 22 rank A patients (23.7%), 15 rank B (18.3%) and 49 rank C (40.2%). In the univariate analysis, preoperative AICS (lung) rank C was a worse factor of recurrence-free survival (p = 0.0002). The multivariate analysis identified preoperative AICS (lung) rank C (HR: 2.17, p = 0.0005) as a significant predictor of postoperative recurrence, particularly in patients with early-stage disease or adenocarcinoma.ConclusionPreoperative AICS (lung) rank C is a high-risk predictor of postoperative recurrence in patients undergoing curative resection for NSCLC.

【 授权许可】

CC BY