Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19)

BMC Cardiovascular Disorders

Guodong Tang¹  Fang Wang¹  Bing Liu¹  You Lv¹  Hui Li¹  Jing Gao²  Yinghua Zhang²  Jing Li³  Chunyi Fu⁴  Zhigang Chang⁵  Aihua Liu⁶ 

[1] Division of Cardiology, Beijing Hospital, #1 Dahua Road, Dongcheng District, 100730, Beijing, China;Division of Cardiology, Xuanwu Hospital Capital Medical University, #45 Changchun Street, Xicheng District, 100053, Beijing, China;Division of Cardiology, Xuanwu Hospital Capital Medical University, #45 Changchun Street, Xicheng District, 100053, Beijing, China;National Center Research Center of Geriatric Diseases [Xuanwu Hospital], 100053, Beijing, China;Division of Emergency, Beijing Hospital, 100730, Beijing, China;Division of Intensive Care Unit, Beijing Hospital, 100730, Beijing, China;Division of Rheumatology and Immunology, Beijing Hospital, 100730, Beijing, China;

关键词: Coronavirus;    Severe pneumonia;    Cardiac damage;   

DOI  :  10.1186/s12872-020-01758-w

来源: Springer

【 摘 要 】

BackgroundCoronavirus disease 2019 (COVID-19) has become a global pandemic. Studies showed COVID-19 affected not only the lung but also other organs. In this study, we aimed to explore the cardiac damage in patients with COVID-19.MethodsWe collected data of 100 patients diagnosed as severe type of COVID-19 from February 8 to April 10, 2020, including demographics, illness history, physical examination, laboratory test, and treatment. In-hospital mortality were observed. Cardiac damage was defined as plasma hypersensitive troponin I (hsTnI) over 34.2 pg/ml and/or N-terminal-pro brain natriuretic peptide (NTproBNP) above 450 pg/ml at the age < 50, above 900 pg/ml at the age < 75, or above 1800 pg/ml at the age ≥ 75.ResultsThe median age of the patients was 62.0 years old. 69 (69.0%) had comorbidities, mainly presenting hypertension, diabetes, and cardiovascular disease. Fever (69 [69.0%]), cough (63 [63.0%]), chest distress (13 [13.0%]), and fatigue (12 [12.0%]) were the common initial symptoms. Cardiac damage occurred in 25 patients. In the subgroups, hsTnI was significantly higher in elder patients (≥ 60 years) than in the young (median [IQR], 5.2 [2.2–12.8] vs. 1.9 [1.9–6.2], p = 0.018) and was higher in men than in women (4.2 [1.9–12.8] vs. 2.9 [1.9–7.4], p = 0.018). The prevalence of increased NTproBNP was significantly higher in men than in women (32.1% vs. 9.1%, p = 0.006), but was similar between the elder and young patients (20.0% vs. 25.0%, p = 0.554). After multivariable analysis, male and hypertension were the risk factors of cardiac damage. The mortality was 4.0%.ConclusionsCardiac damage exists in patients with the severe type of COVID-19, especially in male patients with hypertension. Clinicians should pay more attention to cardiac damage.

【 授权许可】

CC BY