Pain sensitivity in young adults with juvenile idiopathic arthritis: a quantitative sensory testing study

Arthritis Research & Therapy

Marite Rygg¹  Johanne Marie Iversen²  Martin Uglem³  Trond Sand³  Mia Glerup⁴  Ellen Dalen Arnstad⁵  Pål Richard Romundstad⁶ 

[1] Department of Clinical and Molecular Medicine, NTNU—Norwegian University of Science and Technology, Trondheim, Norway;Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway;Department of Internal Medicine, Nordland Hospital, Bodø, Norway;Department of Neuromedicine and Movement Science, NTNU—Norwegian University of Science and Technology, Trondheim, Norway;Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim, Norway;Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark;Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway;Department of Clinical and Molecular Medicine, NTNU—Norwegian University of Science and Technology, Trondheim, Norway;Department of Public Health and Nursing, NTNU—Norwegian University of Science and Technology, Trondheim, Norway;

关键词: Juvenile idiopathic arthritis (JIA);    Young adults;    Long-term outcomes;    Quantitative sensory testing (QST);    Pain threshold;    Pain perception;    Pain sensitivity;    Pain sensitization;    Self-reported pain;   

DOI  :  10.1186/s13075-020-02345-2

来源: Springer

【 摘 要 】

BackgroundTo study for the first-time, pain perception, pain sensitivity, and self-reported pain in young adults with long disease duration of juvenile idiopathic arthritis (JIA) compared with controls.MethodsChildren from Central Norway diagnosed with JIA between 1997 and 2004 were included consecutively in a population-based prospective study. Children with onset 1997–2000 were part of the Nordic JIA cohort. Controls were age- and sex-matched. In 2015–2017, study visits with investigator-blinded quantitative sensory testing (QST) comprising cold and warm detection thresholds (CDT/WDT), cold and heat pain thresholds (CPT/HPT), pressure pain threshold (PPT), and a suprathreshold heat pain test were performed. We constructed separate multilevel models for each variable of detection and pain thresholds with interaction between groups and site adjusted for the effect of age and sex.ResultsAmong 96 young adults with JIA, 71% were female, median age was 22.7 years, disease duration was 16.1 years, and 47% had oligoarticular disease. Among 109 controls, 71% were female, and median age was 23.5 years. Participants with JIA had lower pressure pain thresholds (PPTs) (95% CI) compared to controls, upper limb 888 (846,930) versus 1029 (999,1059) kPa and lower limb 702 (670,734) versus 760 (726,794) kPa. Participants with inactive disease had the lowest PPTs and cold pain thresholds (CPTs), compared to those in remission off medication and those with active disease. Minor differences were found regarding CDT/WDT and CPT/HPT in JIA compared to controls. The median (IQR) temperature needed to evoke pain = 6 on a 0–10 numeric rating scale (NRS) in the suprathreshold heat pain tests were lower in JIA than in controls (46 °C (45–47 °C) versus 47 °C (46–48 °C)). We found no associations between self-reported pain and pain thresholds.ConclusionsOur results indicate for the first time that young adults with long disease duration of JIA may have altered pain perception and sensitivity compared to controls. A clinical implication may be the importance of early treatment to quickly achieve pain-free remission and avoid long-term pain sensitization.

【 授权许可】

CC BY