Non coding RNAs as the critical factors in chemo resistance of bladder tumor cells

Diagnostic Pathology

Meysam Moghbeli¹  Majid Mojarrad¹  Hamid Reza Rahimi¹  Amir Sadra Zangouei² 

[1] Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;

关键词: Bladder cancer;    LncRNA;    MiRNA;    Drug resistance;    Chemotherapy;    Prognosis;    Marker;   

DOI  :  10.1186/s13000-020-01054-3

来源: Springer

【 摘 要 】

BackgroundBladder cancer (BCa) is the ninth frequent and 13th leading cause of cancer related deaths in the world which is mainly observed among men. There is a declining mortality rates in developed countries. Although, the majority of BCa patients present Non-Muscle-Invasive Bladder Cancer (NMIBC) tumors, only 30% of patients suffer from muscle invasion and distant metastases. Radical cystoprostatectomy, radiation, and chemotherapy have proven to be efficient in metastatic tumors. However, tumor relapse is observed in a noticeable ratio of patients following the chemotherapeutic treatment. Non-coding RNAs (ncRNAs) are important factors during tumor progression and chemo resistance which can be used as diagnostic and prognostic biomarkers of BCa.Main bodyIn present review we summarized all of the lncRNAs and miRNAs associated with chemotherapeutic resistance in bladder tumor cells.ConclusionsThis review paves the way of introducing a prognostic panel of ncRNAs for the BCa patients which can be useful to select a proper drug based on the lncRNA profiles of patients to reduce the cytotoxic effects of chemotherapy in such patients.

【 授权许可】

CC BY