Transdiagnostic treatment of emotional disorders in people with multiple sclerosis: randomized controlled trial

BMC Psychology

Ezatolah Ghadampour¹  Davod Mirzaeefar¹  Nabi Nazari¹  Masood Sadeghi¹ 

[1] Department of Psychology, Faculty of Human Sciences, Lorestan University, Khorramabad, Iran;

关键词: Unified protocol;    Emotion regulation;    Transdiagnostic;    Depression;    Anxiety trial registration authority;   

DOI  :  10.1186/s40359-020-00480-8

来源: Springer

【 摘 要 】

BackgroundMultiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. MS is significantly associated with a high rate of psychological, behavioral, and emotional consequences. Despite the frequent mental disorders, high rate of psychological comorbidities, and emotional problems in people with MS (PwMS), these conditions are often underdiagnosed and undertreated. This study aimed to examine the efficacy of a group format of the unified protocol for the transdiagnostic treatment of emotional disorders in adult PwMS associated with an emotional disorder.MethodsSeventy adult PwMS were randomized using an internet-based computer system to either the unified protocol (n = 35) or treatment as usual condition. The assessment protocol included semi-structured clinical interviews and self-reports evaluating diagnostic criteria, depression, anxiety and worry symptoms, emotional dysregulation, and affectivity.ResultsThe parametric test of analysis of covariance, followed the intent to treat analyses, revealed the unified protocol significantly changed depression symptoms (Cohen’s d = 1.9), anxiety symptoms (Cohen’s d = 2.16), worry symptoms (Cohen’s d = 1.27), emotion dysregulation (Cohen’s d = 0.44), positive affect (Cohen’s d = 1.51), and negative affect (Cohen’s d = 1.89) compared with the control group. The unified protocol also significantly improved outcome scores at the end of treatment relative to baseline (p < .001).ConclusionThe findings support that the unified protocol could be an additional efficient psychological treatment for PwMS.Trial registration IRCT, number: IRCT20190711044173N1. Registered 31october 2019, https://en.irct.ir/user/trial/40779/view.

【 授权许可】

CC BY