The role of passive immunization in the age of SARS-CoV-2: an update

European Journal of Medical Research

Torsten Feldt¹  Dieter Häussinger¹  Detlef Kindgen-Milles²  Artur Lichtenberg³  Marion Schneider⁴  Wilfried Budach⁵  Christiane Matuschek⁵  Freddy Joel Djiepmo-Njanang⁵  Jan Haussmann⁵  Balint Tamaskovics⁵  Edwin Bölke⁵  Ute Ganswindt⁶  Stefanie Corradini⁷  Wolfram Trudo Knoefel⁸  Hubert Schelzig⁹  Matthias Peiper^1,10  Johannes C. Fischer^1,11  Martijn van Griensven^1,12  Hans Bojar^1,13  Kurt Zänker^1,14 

[1] Clinic of Gastroenterology, Hepatology und Infectious Diseases, Heinrich Heine University, Düsseldorf, Germany;Department of Anesthesiology and Intensive Care Medicine, Heinrich Heine University, Düsseldorf, Germany;Department of Cardiac Surgery, Heinrich Heine University, Düsseldorf, Germany;Department of Experimental Anesthesiology, University of Ulm, Ulm, Germany;Department of Radiation Oncology, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany;Department of Radiation Oncology, Innsbruck, Austria;Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany;Department of Surgery, Heinrich Heine University, Düsseldorf, Germany;Department of Vascular Surgery, Heinrich Heine University, Düsseldorf, Germany;Heinrich-Heine-University, Düsseldorf, Germany;Institute for Transplant Diagnostics and Cell Therapeutics, Heinrich Heine University, Düsseldorf, Germany;MERLN Institute for Technology-Inspired Regenerative Medicine, Department cBITE, Maastricht University, Maastricht, The Netherlands;NEXTGEN ONCOLOGY GROUP, Düsseldorf, Germany;The Nanjing Han & Zaenker Cancer Institute, Nanjing and Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing Tech University, Jiangsu, China;

关键词: Convalescent plasma;    Covid-19;    High risk;    Bridge therapy;    Intensive care unit;    Respiratory failure;    Immunology;   

DOI  :  10.1186/s40001-020-00414-5

来源: Springer

【 摘 要 】

The rapid spread of the corona virus pandemic is an existential problem for many people in numerous countries. So far, there is no effective vaccine protection or proven therapy available against the SARS-CoV-2 virus. In this review, we describe the role of passive immunization in times of the corona virus. Passive immunization could be a bridging technology to improve the immune defense of critically ill patients until better approaches with effective medications are available.

【 授权许可】

CC BY