Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity

Molecular Neurodegeneration

Annie Y. Yao¹  Riqiang Yan¹ 

[1] Department of Neuroscience, University of Connecticut Health, Farmington, CT, USA;

关键词: Γ-secretase;    Presenilin;    Nicastrin;    Interferon-induced transmembrane protein;    IFITM3;    Innate immunity;    Photo-crosslinking;    Amyloid plaques;    Alzheimer’s disease;   

DOI  :  10.1186/s13024-020-00417-0

来源: Springer

【 摘 要 】

The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3.

【 授权许可】

CC BY