ZBTB7A functioned as an oncogene in colorectal cancer

BMC Gastroenterology

Meng-Xia Zhang¹  Mei-Fang Zhang²  Li Wang³  Zi-Wei Tu⁴ 

[1] Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, Guangdong, China;Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 510060, Guangzhou, Guangdong, China;Department of Radiotherapy, Eye & ENT Hospital, Shanghai Medical College, Fudan University, 200000, Shanghai, China;Department of Radiotherapy, Jiangxi Cancer Hospital, Medical College, Nanchang University, No. 519, Beijing East Road, Qingshan Lake District, 330029, Nanchang, Jiangxi, China;

关键词: ZBTB7A;    Oncogene;    Colorectal cancer (CRC);    Prognosis;    Biomarker;   

DOI  :  10.1186/s12876-020-01456-z

来源: Springer

【 摘 要 】

BackgroundDespite zinc finger and BTB domain-containing 7A (ZBTB7A) documented importance in multiple tumors, the function and clinical value in Colorectal cancer (CRC) remain elusive. The aim of this study was to evaluate the functional roles and the clinical value of ZBTB7A in CRC progression.MethodsThe level of ZBTB7A was detected in a large cohort of CRC patients (n = 189) by immunohistochemistry (IHC), and we analyzed the diagnostic and prognostic value of the protein. In addition, the functional roles of ZBTB7A on CRC were explored in vitro and in vivo.ResultsSurvival analyses indicated that patients with high ZBTB7A expression made the prognosis worse (P = 0.024). Functionally, knockdown of ZBTB7A could markedly inhibit tumor proliferation in vitro and in vivo, whereas ZBTB7A overexpression displayed the opposite results.ConclusionsZBTB7A was associated with poor survival outcomes and functioned as an oncogene in CRC patients, indicating that it is a potential prognostic biomarker and therapeutic target for CRC patients.

【 授权许可】

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