BMC Medicine | |
Individual and combined associations between cardiorespiratory fitness and grip strength with common mental disorders: a prospective cohort study in the UK Biobank | |
Karmel W. Choi1  Brendon Stubbs2  Aaron A. Kandola3  David P. J. Osborn4  Joseph F. Hayes4  | |
[1] Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Psychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA;Stanley Center for Psychiatric Research, Broad Institute, Boston, MA, USA;Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, UK;Physiotherapy Department, South London, and Maudsley National Health Services Foundation Trust, London, UK;Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Rd, W1T 7BN, London, UK;Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Rd, W1T 7BN, London, UK;Camden and Islington NHS Foundation Trust, London, UK; | |
关键词: Fitness; Depression; Anxiety; Physical activity; Exercise; Cardiorespiratory; Grip strength; Muscular; Prevention; | |
DOI : 10.1186/s12916-020-01782-9 | |
来源: Springer | |
【 摘 要 】
BackgroundDepression and anxiety are common mental disorders that increase physical health risks and are leading causes of global disability. Several forms of physical fitness could be modifiable risk factors for common mental disorders in the population. We examined associations between individual and combined markers of cardiorespiratory fitness and grip strength with the incidence of common mental disorders.MethodsA 7-year prospective cohort study in 152,978 UK Biobank participants. An exercise test and dynamometer were used to measure cardiorespiratory and grip strength, respectively. We used Patient Health Questionnaire-9 and Generalised Anxiety Disorder-7 scales to estimate the incidence of common mental disorders at follow-up.ResultsFully adjusted, longitudinal models indicated a dose-response relationship. Low and medium cardiorespiratory fitness was associated with 1.485 (95% CIs, 1.301 to 1.694, p < 0.001) and 1.141 (95% CIs, 1.005 to 1.297, p = 0.041) higher odds of depression or anxiety, compared to high cardiorespiratory fitness. Low and medium grip strength was associated with 1.381 (95% CIs, 1.315 to 1.452, p < 0.001) and 1.116 (95% CIs, 1.063 to 1.172, p < 0.001) higher odds of common mental disorder compared to high grip strength.Individuals in the lowest group for both cardiorespiratory fitness and grip strength had 1.981 (95% CIs, 1.553 to 2.527, p < 0.001) higher odds of depression, 1.599 (95% CIs, 1.148 to 2.118, p = 0.004) higher odds of anxiety, and 1.814 (95% CIs, 1.461 to 2.252, p < 0.001) higher odds of either common mental disorder, compared to high for both types of fitness.ConclusionsObjective cardiorespiratory and muscular fitness markers represent modifiable risk factors for common mental disorders. Public health strategies to reduce common mental disorders could include combinations of aerobic and resistance activities.
【 授权许可】
CC BY
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