Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic

BMC Ophthalmology

Arkasubhra Ghosh¹  Govindasamy Kumaramanickavel¹  Amitabha Chaudhuri²  Nagasamy Soumittra³  J. Somasekar³  Chandrasekar Thangapandi³  Praveen Raj³  Susmithasane Mangalapudi³  Durgesh Kumar³  Dandayudhapani Sudha³  B. Muthu Narayanan³  Sushma Tejwani⁴  Sankar Das⁴  Narendra Pindipappanahalli⁴  Rohit Shetty⁴ 

[1] GROW lab, Narayana Nethrayala Foundation, Bengaluru, India;MedGenome Inc, Foster City, USA;MedGenome Labs Limited, 3rd Floor, Narayana Nethralaya Building, Narayana Health City, #258/A, Bommasandra, Hosur Road, 560099, Bengaluru, Karnataka, India;Narayana Nethralaya, Bengaluru, India;

关键词: Ophthatome;    Knowledge base;    Electronic medical records;    Curated clinical data;    Defined cohort;    Vision sciences;   

DOI  :  10.1186/s12886-020-01705-5

来源: Springer

【 摘 要 】

BackgroundMedical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progression and management, disease surveillance, overall impact on public health and research. Although, the electronic medical records (EMR) system is the digital storehouse of rich medical data of a large patient cohort collected over many years, the data lack sufficient structure to be of clinical value for applying deep learning methods and advanced analytics to improve disease management at an individual patient level or for the discipline in general. Ophthatome™ captures data contained in retrospective electronic medical records between September 2012 and January 2018 to facilitate translational vision research through a knowledgebase of ophthalmic diseases.MethodsThe electronic medical records data from Narayana Nethralaya ophthalmic hospital recorded in the MS-SQL database was mapped and programmatically transferred to MySQL. The captured data was manually curated to preserve data integrity and accuracy. The data was stored in MySQL database management system for ease of visualization, advanced search functions and other knowledgebase applications.ResultsOphthatome™ is a comprehensive and accurate knowledgebase of ophthalmic diseases containing curated clinical, treatment and imaging data of 581,466 ophthalmic subjects from the Indian population, recorded between September 2012 and January 2018. Ophthatome™ provides filters and Boolean searches with operators and modifiers that allow selection of specific cohorts covering 524 distinct ophthalmic disease types and 1800 disease sub-types across 35 different anatomical regions of the eye. The availability of longitudinal data for about 300,000 subjects provides additional opportunity to perform clinical research on disease progression and management including drug responses and management outcomes. The knowledgebase captures ophthalmic diseases in a genetically diverse population providing opportunity to study genetic and environmental factors contributing to or influencing ophthalmic diseases.ConclusionOphthatome™ will accelerate clinical, genomic, pharmacogenomic and advanced translational research in ophthalmology and vision sciences.

【 授权许可】

CC BY