The COVID-19 nephrology compendium: AKI, CKD, ESKD and transplantation

BMC Nephrology

Steven P. Menez¹  Daniel C. Brennan¹  C. John Sperati¹  Derek M. Fine¹  Sam Kant¹  Mohamed Hanouneh²  Bernard G. Jaar³  Deidra C. Crews⁴ 

[1] Department of Medicine, Johns Hopkins School of Medicine, 5601 Loch Raven Boulevard, Suite 3 North, 21205, Baltimore, MD, USA;Department of Medicine, Johns Hopkins School of Medicine, 5601 Loch Raven Boulevard, Suite 3 North, 21205, Baltimore, MD, USA;Nephrology Center of Maryland, Baltimore, MD, USA;Department of Medicine, Johns Hopkins School of Medicine, 5601 Loch Raven Boulevard, Suite 3 North, 21205, Baltimore, MD, USA;Nephrology Center of Maryland, Baltimore, MD, USA;Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA;Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;Department of Medicine, Johns Hopkins School of Medicine, 5601 Loch Raven Boulevard, Suite 3 North, 21205, Baltimore, MD, USA;Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA;

关键词: AKI;    CKD;    ESKD;    Transplantation;    Disparity;    CoVID-19;   

DOI  :  10.1186/s12882-020-02112-0

来源: Springer

【 摘 要 】

The pandemic of coronavirus disease 2019 (CoVID-19) has been an unprecedented period. The disease afflicts multiple organ systems, with acute kidney injury (AKI) a major complication in seriously ill patients. The incidence of AKI in patients with CoVID-19 is variable across numerous international studies, but the high incidence of AKI and its associated worse outcomes in the critical care setting are a consistent finding. A multitude of patterns and mechanisms of AKI have been elucidated, and novel strategies to address shortage of renal replacement therapy equipment have been implemented. The disease also has had consequences on longitudinal management of patients with chronic kidney disease and end stage kidney disease. Kidney transplant recipients may be especially susceptible to CoVID-19 as a result of immunosuppression, with preliminary studies demonstrating high mortality rates. Increased surveillance of disease with low threshold for testing and adjustment of immunosuppression regimen during acute periods of illness have been recommended.

【 授权许可】

CC BY