Influence of biodegradable polymer membrane on new bone formation and biodegradation of biphasic bone substitutes: an animal mandibular defect model study

Maxillofacial Plastic and Reconstructive Surgery

Jeong-Kui Ku¹  Pil-Young Yun²  Young-Kyun Kim³ 

[1]Department of Oral and Maxillofacial Surgery, Section of Dentistry, Section of Dentistry, Armed Forces Capital Dental Hospital, Armed Forces Medical Command, 81, Saemaul-ro 117, 13634, Seongnam, Bundang-gu, Korea

[2]Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, 300 Gumi-dong, 463-707, Bundang-gu, Gyeonggi-do, Korea

[3]Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, 300 Gumi-dong, 463-707, Bundang-gu, Gyeonggi-do, Korea

[4]Department of Dentistry and Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, 03080, Seoul, Jongno-gu, Korea

关键词: Beta-tricalcium phosphate;    Biphasic calcium phosphate;    Bone regeneration;    Hydroxyapatite;    Membrane;    Polycaprolactone;   

DOI  :  10.1186/s40902-020-00280-5

来源: Springer

【 摘 要 】

PurposeThe purpose of this study was to evaluate the influence of biodegradable polycaprolactone membrane on new bone formation and the biodegradation of biphasic alloplastic bone substitutes using animal models.Materials and methodsIn this study, bony defect was formed at the canine mandible of 8 mm in diameter, and the defects were filled with Osteon II. The experimental groups were covered with Osteoguide as barrier membrane, and the control groups were closed without membrane coverage. The proportion of new bone and residual bone graft material was measured histologically and histomorphometrically at postoperative 4 and 8 weeks.ResultsAt 4 weeks, the new bone proportion was similar between the groups. The proportion of remaining graft volume was 27.58 ± 6.26 and 20.01 ± 4.68% on control and experimental groups, respectively (P < 0.05). There was no significant difference between the two groups in new bone formation and the amount of residual bone graft material at 8 weeks.ConclusionThe biopolymer membrane contributes to early biodegradation of biphasic bone substitutes in the jaw defect but it does not affect the bone formation capacity of the bone graft.

【 授权许可】

CC BY