The effect of an online exercise programme on bone health in paediatric cancer survivors (iBoneFIT): study protocol of a multi-centre randomized controlled trial

BMC Public Health

Maria J. Sánchez¹  Manuel Arroyo-Morales²  Manuel Muñoz-Torres³  Dimitris Vlachopoulos⁴  Ana I. Benito-Bernal⁵  Idoia Labayen⁶  Francisco J. Llorente-Cantarero⁷  Francisco B. Ortega⁸  Jonatan R. Ruiz⁸  Esther Ubago-Guisado⁸  Luis Gracia-Marco⁸  Jose J. Gil-Cosano⁸  Maria C. Vicho-González⁹  Maria E. Mateos^1,10  Juan F. Pascual-Gázquez^1,11  Maria J. Ortega-Acosta^1,11  Vicente Martinez-Vizcaino^1,12 

[1] Andalusian School of Health (EASP), Granada, Spain;Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain;CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain;Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain;Biohealth Research Institute in Granada (ibs.GRANADA), E-18012, Granada, Spain;Department of Physiotherapy, University of Granada, E-18016, Granada, Spain;”Cuídate” Support Unit for Oncology Patients (UAPO), Sport and Health University Research Institute (iMUDS), E-18016, Granada, Spain;Bone Metabolic Unit, Endocrinology and Nutrition Division, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain;CIBERFES, Instituto de Salud Carlos III, Madrid, Spain;Department of Medicine, Universidad de Granada, Granada, Spain;Children’s Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, Exeter, UK;Hospital Infantil Universitario Niño Jesús, Madrid, Spain;Institute for Innovation and Sustainable Development in Food Chain (IS-FOOD), Navarra’s Health Research Institute (IdiSNA), Department of Health Sciences, Public University of Navarra, Calle Tajonar 22, 31006, Pamplona, Navarra, Spain;Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), Córdoba, Spain;CIBEROBN, (Physiopathology of Obesity and Nutrition) Institute of Health Carlos III (ISCIII), 28029, Madrid, Spain;Department of Specific Didactics, Faculty of Education, University of Córdoba, 14071, Córdoba, Spain;PROFITH “PROmoting FITness and Health through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, 18071, Granada, Spain;Pediatric Oncology Unit, Department of Pediatrics, Reina Sofia University Hospital, Córdoba, Spain;Pediatric Oncology Unit, Department of Pediatrics, Reina Sofia University Hospital, Córdoba, Spain;Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), Córdoba, Spain;Servicio de Pediatría y Oncohematología Pediátricas, Hospital Universitario Virgen de las Nieves, Granada, Spain;Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain;Faculty of Health Sciences, Universidad Autónoma de Chile, Talca, Chile;

关键词: Telemedicine;    Cancer;    Survivor;    Bone;    Plyometric exercise;    Paediatrics;    Quality of life;   

DOI  :  10.1186/s12889-020-09607-3

来源: Springer

【 摘 要 】

BackgroundNew approaches on paediatric cancer treatment aim to maintain long-term health. As a result of radiotherapy, chemotherapy or surgery, paediatric cancer survivors tend to suffer from any chronic health condition. Endocrine dysfunction represents one of the most common issues and affects bone health. Exercise is key for bone mass accrual during growth, specifically plyometric jump training. The iBoneFIT study will investigate the effect of a 9-month online exercise programme on bone health in paediatric cancer survivors. This study will also examine the effect of the intervention on body composition, physical fitness, physical activity, calcium intake, vitamin D, blood samples quality of life and mental health.MethodsA minimum of 116 participants aged 6 to 18 years will be randomized into an intervention (n = 58) or control group (n = 58). The intervention group will receive an online exercise programme and diet counselling on calcium and vitamin D. In addition, five behaviour change techniques and a gamification design will be implemented in order to increase the interest of this non-game programme. The control group will only receive diet counselling. Participants will be assessed on 3 occasions: 1) at baseline; 2) after the 9 months of the intervention; 3) 4 months following the intervention. The primary outcome will be determined by dual energy X-ray absorptiometry (DXA) and the hip structural analysis, trabecular bone score and 3D-DXA softwares. Secondary outcomes will include anthropometry, body composition, physical fitness, physical activity, calcium and vitamin D intake, blood samples, quality of life and mental health.DiscussionWhether a simple, feasible and short in duration exercise programme can improve bone health has not been examined in paediatric cancer survivors. This article describes the design, rationale and methods of a study intended to test the effect of a rigorous online exercise programme on bone health in paediatric cancer survivors. If successful, the iBoneFIT study will contribute to decrease chronic health conditions in this population and will have a positive impact in the society.Trial registrationProspectively registered in isrctn.com: isrctn61195625. Registered 2 April 2020.

【 授权许可】

CC BY