Improved methods for mass production of magnetosomes and applications: a review

Microbial Cell Factories

Fangfang Guo¹  Wei Jiang²  Wei Niu²  Jiaojiao Wang²  Abdul Basit³ 

[1] Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, BJ, People’s Republic of China;State Key Laboratory of Agro-Biotechnology, College of Biological Sciences, China Agricultural University, 100193, Beijing, China;State Key Laboratory of Agro-Biotechnology, College of Biological Sciences, China Agricultural University, 100193, Beijing, China;Department of Microbiology, Faculty of Life Sciences, University of Okara, 56130, Okara, Pakistan;

关键词: Magnetosome biosynthesis;    high-yield;    cell growth;    culture conditions;    commercial applications;   

DOI  :  10.1186/s12934-020-01455-5

来源: Springer

【 摘 要 】

Magnetotactic bacteria have the unique ability to synthesize magnetosomes (nano-sized magnetite or greigite crystals arranged in chain-like structures) in a variety of shapes and sizes. The chain alignment of magnetosomes enables magnetotactic bacteria to sense and orient themselves along geomagnetic fields. There is steadily increasing demand for magnetosomes in the areas of biotechnology, biomedicine, and environmental protection. Practical difficulties in cultivating magnetotactic bacteria and achieving consistent, high-yield magnetosome production under artificial environmental conditions have presented an obstacle to successful development of magnetosome applications in commercial areas. Here, we review information on magnetosome biosynthesis and strategies for enhancement of bacterial cell growth and magnetosome formation, and implications for improvement of magnetosome yield on a laboratory scale and mass-production (commercial or industrial) scale.

【 授权许可】

CC BY