A case of irreversible bradycardia after rituximab therapy for diffuse large B-cell lymphoma

Cardio-Oncology

Nway Le Ko Ko¹  Nareg Minaskeian¹  Hicham Z. El Masry¹ 

[1] Department of Cardiovascular Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA;

关键词: Rituximab;    High grade AV block;    Complete AV block;    Bradyarrythmia;    Diffuse large B cell lymphoma;   

DOI  :  10.1186/s40959-020-00077-5

来源: Springer

【 摘 要 】

This is a case of a middle-aged woman with underlying cardiac conduction system with episodes of AV Wenckebach, who subsequently developed significant AV conduction system abnormalities after receiving one standard dose of Rituximab infusion for diffuse large B-cell lymphoma. Rituximab, being a monoclonal antibody against CD-20 antigen, is effective in treatment of B-cell lymphoma but may also cause bradyarrythmias likely due to the calcium ion channel property of CD-20 antigen.

【 授权许可】

CC BY