The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma

Respiratory Research

Zhenxing Zhu¹  Shiji Wang²  Zhongmin Liu²  Jing Zhang³  Xu Zuo⁴  Yuze Yuan⁴  He Pan⁴  Yinuo Gu⁴  Fang Wang⁴  Guoqiang Wang⁴  Ruipeng Zheng⁵  Jingtong Zheng⁶ 

[1] Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, 130033, Changchun, China;Department of Intensive Care Unit, First Hospital of Jilin University, 130021, Changchun, China;Department of Intensive Care Unit, First Hospital of Jilin University, 130021, Changchun, China;Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, 130021, Changchun, China;Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, 130021, Changchun, China;Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, 130021, Changchun, China;Department of Interventional Therapy, First Hospital of Jilin University, 130021, Changchun, China;Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, 130021, Changchun, China;Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, 130062, Changchun, China;

关键词: Neutrophilic asthma;    Haemophilus influenzae;    Oxidative stress;    Th17/Treg imbalance;    Corticosteroid-resistant;   

DOI  :  10.1186/s12931-020-01438-5

来源: Springer

【 摘 要 】

Asthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are described as persistent, more severe and corticosteroid-resistant, with higher hospitalization and mortality rates, which seriously affect the lives of asthmatic patients. With the development of high-throughput sequencing technology, an increasing amount of evidence has shown that lower airway microbiome dysbiosis contributes to the exacerbation of asthma, especially neutrophilic asthma. Nontypeable Haemophilus influenzae is normally found in the upper respiratory tract of healthy adults and is one of the most common strains in the lower respiratory tract of neutrophilic asthma patients, in whom its presence is related to the occurrence of corticosteroid resistance. To understand the pathogenic mechanism by which nontypeable Haemophilus influenzae colonization leads to the progression of neutrophilic asthma, we reviewed the previous literature on nontypeable Haemophilus influenzae colonization and subsequent aggravation of neutrophilic asthma and corticosteroid resistance. We discussed nontypeable Haemophilus influenzae as a potential therapeutic target to prevent the progression of neutrophilic asthma.

【 授权许可】

CC BY