Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy

Biophysics Reports

Shixiang Wang¹  Bin Yang²  Ying Tao³  Cong Mao³  Haoting Chen³  Ruslan G. Tuguntaev³  Weisheng Guo³  Yingsi Xie⁴ 

[1] Department of Cardiovascular Medicine, The Third Affiliated Hospital, Guangzhou Medical University, 510260, Guangzhou, China;The Sixth Affiliated Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, 511436, Guangzhou, China;Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University, 510260, Guangzhou, China;Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University, 510260, Guangzhou, China;Université Paris 13, 99 avenue Jean Baptiste Clément, 93430, Villetaneuse, France;

关键词: Rheumatoid arthritis;    Nanotechnology;    Stimuli-responsive polymers;    Drug delivery systems;   

DOI  :  10.1007/s41048-020-00117-8

来源: Springer

【 摘 要 】

Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (i.e., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.

【 授权许可】

CC BY