Prevalence and influencing factors of nonunion in patients with tibial fracture: systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research

Yuhui Zhang¹  Jinping Yuan¹  Ruifeng Tian²  Bowen Zhang²  Liangman Li²  Wei Zhao³  Fang Zheng⁴ 

[1] Department of Dermatology, No.1 Hospital of China Medical University, Guangzhou, China;Department of Orthopaedics, No.1 Hospital of China Medical University, Shenyang, China;Department of Orthopaedics, No.1 Hospital of China Medical University, Shenyang, China;Department of Orthopaedics, No.4 Hospital of China Medical University, Guangzhou, China;Department of Orthopaedics, No.1 Hospital of China Medical University, Shenyang, China;Department of Orthopaedics, Shenyang Orthopaedic Hospital, Shenyang, China;

关键词: Tibia fracture;    Nonunion;    Prevalence;    Influencing factors;    Systematic review;   

DOI  :  10.1186/s13018-020-01904-2

来源: Springer

【 摘 要 】

ObjectiveThe aim of this study is to assess the prevalence of nonunion in patients with tibia fracture and the association between influencing factors and tibia fracture nonunion.MethodA database searches of PubMed, the Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Weipu database, and Wanfang database from inception until June 2019 was conducted. The pooled prevalence, odds ratio (OR), and 95% confidence intervals (CI) were calculated with Stata software.ResultsIn this study, 111 studies involving 41,429 subjects were included. In the study of the relationship between influencing factors and tibia fracture nonunion, 15 factors significantly influenced the fracture union, including > 60 years old, male, tobacco smoker, body mass index > 40, diabetes, nonsteroidal anti-inflammatory drugs (NSAIDs) user, opioids user, fracture of middle and distal tibia, high-energy fracture, open fracture, Gustilo-Anderson grade IIIB or IIIC, Müller AO Classification of Fractures C, open reduction, fixation model, and infection.ConclusionThe prevalence of nonunion in patients with tibia fracture was 0.068 and 15 potential factors were associated with the prevalence. Closed reduction and minimally invasive percutaneous plate osteosynthesis (MIPPO) have the low risks of nonunion for the treatment of tibial fractures.

【 授权许可】

CC BY