Establishment of prognostic nomogram for elderly colorectal cancer patients: a SEER database analysis

BMC Gastroenterology

Yujie Zhang¹  Chaoran Yu² 

[1] Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, China;Fudan University Shanghai Cancer Center, Fudan University, Dongan Road 270, 200025, Shanghai, P. R. China;Department of Oncology, Shanghai Medical College, Fudan University, Dongan Road 270, 200025, Shanghai, P. R. China;

关键词: Elderly colon cancer;    Nomogram;    Overall survival;    Cancer-specific survival;    SEER;   

DOI  :  10.1186/s12876-020-01464-z

来源: Springer

【 摘 要 】

BackgroundThis study aimed to establish nomogram models of overall survival (OS) and cancer-specific survival (CSS) in elderly colorectal cancer (ECRC) patients (Age ≥ 70).MethodsThe clinical variables of patients confirmed as ECRC between 2004 and 2016 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate analysis were performed, followed by the construction of nomograms in OS and CSS.ResultsA total of 44,761 cases were finally included in this study. Both C-index and calibration plots indicated noticeable performance of newly established nomograms. Moreover, nomograms also showed higher outcomes of decision curve analysis (DCA) and the area under the curve (AUC) compared to American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) stage and SEER stage.ConclusionsThis study established nomograms of elderly colorectal cancer patients with distinct clinical values compared to AJCC TNM and SEER stages regarding both OS and CSS.

【 授权许可】

CC BY