Aging-related tumor associated fibroblasts changes could worsen the prognosis of GBM patients

Cancer Cell International

Hongwang Song¹  Xiaojun Fu²  Chenxing Wu²  Shouwei Li² 

[1] Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, China;Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Xiangshanyikesong 50#, HaiDian District, 100093, Beijing, China;

关键词: Glioblastoma;    Tumor heterogeneity;    Tumor microenvironment;    Tumor associated fibroblasts;    Epithelial mesenchymal transition;   

DOI  :  10.1186/s12935-020-01571-7

来源: Springer

【 摘 要 】

BackgroundGlioblastoma multiforme (GBM) is the most malignant tumor in human brain, with highly heterogeneity among different patients. Age could function as an incidence and prognosis risk factor for many tumors.MethodA series of bioinformatic experiments were conducted to evaluate the differences of incidence, differential expressed genes, enriched pathways with the data from Surveillance, Epidemiology, and End Results (SEER) program, the cancer genome atlas (TCGA) and Chinese glioma genome atlas (CGGA) project.ResultsWe discovered in our present study that distinct difference of incidence and prognosis of different aged GBM patients. By a series of bioinformatic method, we found that the tumor associated fibroblasts (TAFs) was the most crucial tumor microenvironment (TME) component that led to this phenomenon. Epithelial-mesenchymal transition (EMT) could be the mechanism by which TAFs regulate the progression of GBM.ConclusionWe have proposed a close correlation between age and GBM incidence and prognosis, and propose the underlying mechanism behind this correlation by mining different databases, which laid the foundation for future research.

【 授权许可】

CC BY