Association of dietary inflammatory potential with cardiometabolic risk factors and diseases: a systematic review and dose–response meta-analysis of observational studies

Diabetology & Metabolic Syndrome

Nitin Shivappa¹  James R. Hébert¹  Fereshteh Baygi²  Motahar Heidari-Beni³  Gity Sotoudeh⁴  Omid Sadeghi⁵  Zahra Aslani⁵  Hamid Asayesh⁶  Shirin Djalalinia⁷  Sajjad Moradi⁸  Hoda Zahedi⁹  Mostafa Qorbani^1,10 

[1] Cancer Prevention and Control Program, University of South Carolina, 29208, Columbia, SC, USA;Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 29208, Columbia, SC, USA;Connecting Health Innovations LLC, 29201, Columbia, SC, USA;Center of Maritime Health and Society, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark;Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran;Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran;Development of Research & Technology Center, Ministry of Health and Medical Education, Tehran, Iran;Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;Halal Research Center of IRI, FDA, Tehran, Iran;Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran;Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Diet;    Inflammation;    Cardiovascular diseases;    Dietary inflammatory index;   

DOI  :  10.1186/s13098-020-00592-6

来源: Springer

【 摘 要 】

ContextThe association of dietary inflammatory index (DII®), as an index of inflammatory quality of diet, with cardiometabolic diseases (CMDs) and risk factors (CMRFs) has been inconsistent in previous studies.ObjectiveThe current systematic review and dose–response meta-analysis was performed to investigate the association of the DII score with CMDs and CMRFs.Data SourcesAll published observational studies (cohort, case–control and cross-sectional) using PubMed/Medline, Scopus, ISI Web of Science, and Google Scholar databases were retrieved from inception through November 2019.Data extractionTwo reviewers independently extracted the data from included studies.Data analysisPooled hazard ratio (HR) or odds ratio (OR) were calculated by using a random-effects model.ResultsTen prospective cohort studies (total n = 291,968) with 31,069 CMDs-specific mortality, six prospective cohort studies (total n = 43,340) with 1311 CMDs-specific morbidity, two case–control studies with 2140 cases and 6246 controls and one cross-sectional study (total n = 15,613) with 1734 CMDs-specific morbidity were identified for CMDs. Meta-analyses of published observational studies demonstrated that the highest DII score category versus the lowest DII score category was associated with 29% increased risk of CMDs mortality (HR = 1.29; 95% confidence interval (CI) 1.18, 1.41). Moreover, there was a significant association between the DII score and risk of CMDs in cohort studies (HR = 1.35; 95% CI 1.13, 1.61) and non-cohort study (HR = 1.36; 95% CI 1.18, 1.57). We found a significant association between the DII score and metabolic syndrome (MetS) (OR: 1.13; 95% CI 1.03, 1.25), hyperglycemia and hypertension. None-linear dose response meta-analysis showed that there was a significant association between the DII score and risk of CMDs mortality (Pnonlinearity < 0.001). Moreover, evidence of none-linear association between the DII score and risk of CMDs was not observed (p-value = 0.1).ConclusionsAdherence to pro-inflammatory diet was associated with increased risk of CMDs, mortality and MetS.

【 授权许可】

CC BY