Gut-liver crosstalk in sepsis-induced liver injury

Critical Care

Yongjie Yin¹  Jiakun Tian¹  Fuxi Ji¹  Jingxiao Zhang²  Jian Sun²  Xiangfeng Wang³  Claudio Ronco⁴ 

[1] Department of Emergency and Critical Care Medicine, Second Hospital of Jilin University, Changchun, Jilin Province, China;Department of Emergency and Critical Care Medicine, Second Hospital of Jilin University, Changchun, Jilin Province, China;International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy;Department of Pharmacy, First Hospital of Jilin University, Changchun, Jilin Province, China;International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy;Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy;

关键词: Sepsis;    Liver injury;    Gut-liver crosstalk;    Inflammation;    Metabolism;    Microbiota dysbiosis;   

DOI  :  10.1186/s13054-020-03327-1

来源: Springer

【 摘 要 】

Sepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality in the intensive care unit. During systemic infections, the liver regulates immune defenses via bacterial clearance, production of acute-phase proteins (APPs) and cytokines, and metabolic adaptation to inflammation. Increased levels of inflammatory cytokines and impaired bacterial clearance and disrupted metabolic products can cause gut microbiota dysbiosis and disruption of the intestinal mucosal barrier. Changes in the gut microbiota play crucial roles in liver injury during sepsis. Bacterial translocation and resulting intestinal inflammation lead to a systemic inflammatory response and acute liver injury. The gut-liver crosstalk is a potential target for therapeutic interventions. This review analyzes the underlying mechanisms for the gut-liver crosstalk in sepsis-induced liver injury.

【 授权许可】

CC BY