Primary localized retroperitoneal sarcomas: report from Slovenian sarcoma referral center

World Journal of Surgical Oncology

Milena Kerin Povšič¹  Matej Arnuš¹  Marko Novak²  Andraž Perhavec²  Darja Eržen² 

[1] Department of Anesthesiology and Intensive Care, Institute of Oncology Ljubljana, Zaloška 2, 1105, Ljubljana, Slovenia;Department of Surgical Oncology, Institute of Oncology Ljubljana, Zaloška 2, 1105, Ljubljana, Slovenia;

关键词: Retroperitoneal sarcoma;    Referral center;    Surgery;    Survival;   

DOI  :  10.1186/s12957-020-02038-9

来源: Springer

【 摘 要 】

BackgroundSarcoma patients should be treated in high volume referral sarcoma centers. Compartmental resection is proposed as the best treatment option in retroperitoneal sarcoma patients.MethodsInstitute of Oncology Ljubljana is the only referral sarcoma center in Slovenia. Having a population of 2.1 million poses a unique situation. We manage all sarcoma patients in the country and operate on patients with soft tissue tumors of extremities, trunk, and abdomen. Data for all consecutive patients surgically treated from January 1999 to December 2018 for primary localized retroperitoneal sarcoma was extracted from a prospective surgical database. Data about the incidence of sarcoma patients in Slovenia was extracted from the Cancer Registry of Republic of Slovenia. Clinicopathologic variables and the outcome were analyzed.ResultsIn total, 89 patients were included in the study. Median age was 62 years. Dedifferentiated liposarcoma was the most common histology (38.2%). Median tumor size was 21 cm. Compartmental resection was performed in 47.2% (42/89). Postoperative complication grade 3a or higher according to Clavien-Dindo classification had 30.3% (27/89) of patients. The 30-day and 90-day mortality rate was 2.2% and 5.6%. Median follow-up was 62.1 months. Corresponding 5-year overall survival was 67.2%, 5-year disease-specific survival was 72.6%, and 5-year local recurrence-free survival was 81.5%, respectively.ConclusionResults from our institution show that referral sarcoma centers may achieve very good results in management of retroperitoneal sarcoma patients, despite not meeting the criteria for high volume hospitals, as long as they have multidisciplinary team, appropriate facilities, and expertise.

【 授权许可】

CC BY