Recommendations for the adjuvant use of the poly-antibiotic–resistant probiotic Bacillus clausii (O/C, SIN, N/R, T) in acute, chronic, and antibiotic-associated diarrhea in children: consensus from Asian experts

Tropical Diseases, Travel Medicine and Vaccines

Dhanasekhar Kesavelu¹  Keya Rani Lahiri²  Pramod Prabhakar Jog³  Jo-Anne De Castro⁴  Pornthep Tanpowpong⁵  Nataruks Chaijitraruch⁶  Voranush Chongsrisawat⁶  Thi Viet Ha Nguyen⁷  Mary Jean Guno⁸  Yun Haw Liaw⁹  Seng Hock Quak^1,10  Uday Ananth Pai^1,11  Huu Nguyet Diem Phan^1,12  Gia Khanh Nguyen^1,13 

[1] Apollo Children Hospital, Chennai, India;D. Y. Patil Medical College & Hospital, Navi Mumbai, India;D. Y. Patil Medical College, Pune, India;De La Salle University Medical Center, Dasmariñas, Cavite, Philippines;Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand;Hanoi Medical University, Hanoi, Vietnam;Institute of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, The Medical City, Pasig City, Philippines;KPJ Sabah Specialist Hospital, Kota Kinabalu, Sabah, Malaysia;National University Hospital, Singapore, Singapore;Pai’s Clinic, Chembur, Mumbai, India;University of Medicine and Pharmacy of Ho Chi Minh City, Ho Chi Minh City, Vietnam;Vietnam Pediatric Association, Hanoi, Vietnam;

关键词: Acute viral diarrhea;    Antibiotic-associated diarrhea;    Bacillus clausii;    Clostridium difficile;    Chronic diarrhea;    Gastroenteritis;    Helicobacter pylori;    Pediatric diarrhea;    Probiotics;    Spores;   

DOI  :  10.1186/s40794-020-00120-4

来源: Springer

【 摘 要 】

This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Evidence-based recommendations and randomized controlled trials in the region are included. Cultural aspects, health management issues and economic factors were also considered. Final recommendations were approved by utilizing a modified Delphi process and applying the Likert scale in an electronic voting process. Bacillus clausii was recommended as an adjunct treatment with oral rehydration solution for acute viral diarrhea. B. clausii may also be considered for prevention of antibiotic-associated diarrhea, Clostridium difficile-induced diarrhea, and as adjunct treatment of Helicobacter pylori. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological, socioeconomical and health system conditions, similar recommendations currently apply to most Asia-Pacific countries. Ideally, these need to be validated with local randomized-controlled trials.

【 授权许可】

CC BY