Protective effects of Olyset® Net on Plasmodium falciparum infection after three years of distribution in western Kenya

Malaria Journal

George O. Sonye¹  Beatrice Awuor¹  Stephen Munga²  James O. Kongere³  Noboru Minakawa⁴  Noriko Tamari⁵  Muneaki Hashimoto⁶  Masatoshi Kataoka⁶ 

[1] Ability To Solve By Knowledge Project, Mbita, Homa Bay, Kenya;Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya;Centre for Research in Tropical Medicine and Community Development, Nairobi, Kenya;Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Nagasaki, Japan;Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Nagasaki, Japan;College of Public Health, The University of Arizona, 1295 N Martin Ave, 85724, Tucson, AZ, USA;National Institute of Advanced Industrial Science and Technology (AIST), Health Research Institute, Kagawa, Japan;

关键词: Llins;    Olyset®;    DawaPlus® 2.0;    Plasmodium;    Malaria;    Repellent effects;    Permethrin;    Deltamethrin;   

DOI  :  10.1186/s12936-020-03444-w

来源: Springer

【 摘 要 】

BackgroundSeveral types of insecticides, treating technologies and materials are available for long-lasting insecticide-treated nets (LLINs). The variations may result in different efficacies against mosquitoes and correspondingly infection risks for the Plasmodium falciparum malaria parasite. This cross-sectional study investigated whether infection risk varied among children who slept under different LLIN brands in rural villages of western Kenya.MethodsChildren sleeping under various types of LLINs were tested for P. falciparum infection using a diagnostic polymerase chain reaction (PCR) assay. Data were collected for other potential factors associated with infection risk: sleeping location (with bed/without bed), number of persons sharing the same net, dwelling wall material, gap of eaves (open/close), proportional hole index, socio-economic status, and density of indoor resting anophelines. Bed-net efficacy against the Anopheles gambiae susceptible strain was estimated using the WHO cone test and the tunnel test. The residual insecticide content on nets was measured.ResultsSeven LLIN brands were identified, and deltamethrin-based DawaPlus® 2.0 was the most popular (48%) followed by permethrin-based Olyset® Net (28%). The former LLIN was distributed in the area about six months before the present study was conducted, and the latter net was distributed at least three years before. Of 254 children analysed, P. falciparum PCR-positive prevalence was 58% for DawaPlus® 2.0 users and 38% for Olyset® users. The multiple regression analysis revealed that the difference was statistically significant (adjusted OR: 0.67, 95% credible interval: 0.45–0.97), whereas the confounders were not statistically important. Among randomly selected net samples, all DawaPlus® 2.0 (n = 20) and 95% of Olyset® (n = 19) passed either the cone test or the tunnel test.ConclusionsOlyset® was more effective in reducing infection risk compared with DawaPlus® 2.0. Although the data from the present study were too limited to explain the mechanism clearly, the results suggest that the characteristics of the former brand are more suitable for the conditions, such as vector species composition, of the study area.

【 授权许可】

CC BY