The functions and clinical significance of circRNAs in hematological malignancies

Journal of Hematology & Oncology

Kai Huang¹  Linquan Zhan²  Xiangxiang Zhou³  Xin Wang³ 

[1] Department of Chemotherapy, Cancer Center, Qilu Hospital of Shandong University, 250012, Jinan, Shandong, People’s Republic of China;Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 250021, Jinan, Shandong, People’s Republic of China;Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 250021, Jinan, Shandong, People’s Republic of China;Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, Shandong, People’s Republic of China;School of Medicine, Shandong University, 250012, Jinan, Shandong, People’s Republic of China;Shandong Provincial Engineering Research Center of Lymphoma, 250021, Jinan, Shandong, People’s Republic of China;Branch of National Clinical Research Center for Hematologic Diseases, 250021, Jinan, Shandong, People’s Republic of China;National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, 251006, Suzhou, People’s Republic of China;

关键词: Circular RNAs;    Hematological malignancies;    Tumorigenesis;    Drug-resistance;    Biomarker;   

DOI  :  10.1186/s13045-020-00976-1

来源: Springer

【 摘 要 】

With covalently closed circular structures, circular RNAs (circRNAs) were once misinterpreted as by-products of mRNA splicing. Being abundant, stable, highly conserved, and tissue-specific, circRNAs are recently identified as a type of regulatory RNAs. CircRNAs bind to certain miRNAs or proteins to participate in gene transcription and translation. Emerging evidence has indicated that the dysregulation of circRNAs is closely linked to the tumorigenesis and treatment response of hematological malignancies. CircRNAs play critical roles in various biological processes, including tumorigenesis, drug resistance, tumor metabolism, autophagy, pyroptosis, and ferroptosis. The N6-methyladenosine modification of circRNAs and discovery of fusion-circRNAs provide novel insights into the functions of circRNAs. Targeting circRNAs in hematological malignancies will be an attractive treatment strategy. In this review, we systematically summarize recent advances toward the novel functions and molecular mechanisms of circRNAs in hematological malignancies, and highlight the potential clinical applications of circRNAs as novel biomarkers and therapeutic targets for future exploration.

【 授权许可】

CC BY