How to reprogram human fibroblasts to neurons

Cell & Bioscience

Siyan Zhou¹  Wentao Yang²  Xin Deng²  Ziran Xu³  Lisha Li³  Yulin Li³  Yingying Sun⁴  Shengnan Su⁵ 

[1] Department of Stomatology, The First Hospital of Jilin University, 130021, Changchun, People’s Republic of China;Norman Bethune College of Medicine, Jilin University, 130021, Changchun, People’s Republic of China;The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 130021, Changchun, People’s Republic of China;The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 130021, Changchun, People’s Republic of China;Department of Stomatology, The First Hospital of Jilin University, 130021, Changchun, People’s Republic of China;The Second Hospital of Jilin University, 130041, Jilin, Changchun, China;

关键词: Human fibroblasts;    Reprogramming;    Transcriptional factors;    Small molecules;    Physical factors;    Neurons;   

DOI  :  10.1186/s13578-020-00476-2

来源: Springer

【 摘 要 】

Destruction and death of neurons can lead to neurodegenerative diseases. One possible way to treat neurodegenerative diseases and damage of the nervous system is replacing damaged and dead neurons by cell transplantation. If new neurons can replace the lost neurons, patients may be able to regain the lost functions of memory, motor, and so on. Therefore, acquiring neurons conveniently and efficiently is vital to treat neurological diseases. In recent years, studies on reprogramming human fibroblasts into neurons have emerged one after another, and this paper summarizes all these studies. Scientists find small molecules and transcription factors playing a crucial role in reprogramming and inducing neuron production. At the same time, both the physiological microenvironment in vivo and the physical and chemical factors in vitro play an essential role in the induction of neurons. Therefore, this paper summarized and analyzed these relevant factors. In addition, due to the unique advantages of physical factors in the process of reprogramming human fibroblasts into neurons, such as safe and minimally invasive, it has a more promising application prospect. Therefore, this paper also summarizes some successful physical mechanisms of utilizing fibroblasts to acquire neurons, which will provide new ideas for somatic cell reprogramming.

【 授权许可】

CC BY