Pleiotropic roles of cold shock proteins with special emphasis on unexplored cold shock protein member of Plasmodium falciparum

Malaria Journal

Maxim Shevtsov¹  Vikash Kumar²  Shailja Singh²  Ankita Behl² 

[1] Center for Translational Cancer Research Technische Universität München (TranslaTUM), Radiation Immuno-Oncology group, Klinikum rechts der Isar, Einstein Str. 25, 81675, Munich, Germany;Institute of Cytology of the Russian Academy of Sciences (RAS), Tikhoretsky ave., 4, 194064, St. Petersburg, Russia;Pavlov First Saint Petersburg State Medical University, L. Tolstogo str. 6/8, 197022, St. Petersburg, Russia;Almazov National Medical Research Centre, Polenov Russian Scientific Research Institute of Neurosurgery, Mayakovskogo str. 12, 191104, St. Petersburg, Russia;National Center for Neurosurgery, Turan Ave., 34/1, 010000, Nur-Sultan, Kazakhstan;Far Eastern Federal University, Russky Island, 690000, Vladivostok, Russia;Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India;

关键词: Cold shock proteins;    Cold shock domain;    Nucleic acid binding;    YBOX-1;    Plasmodium falciparum;    Gametocytes;   

DOI  :  10.1186/s12936-020-03448-6

来源: Springer

【 摘 要 】

The cold shock domain (CSD) forms the hallmark of the cold shock protein family that provides the characteristic feature of binding with nucleic acids. While much of the information is available on bacterial, plants and human cold shock proteins, their existence and functions in the malaria parasite remains undefined. In the present review, the available information on functions of well-characterized cold shock protein members in different organisms has been collected and an attempt was made to identify the presence and role of cold shock proteins in malaria parasite. A single Plasmodium falciparum cold shock protein (PfCoSP) was found in P. falciparum which is reported to be essential for parasite survival. Essentiality of PfCoSP underscores its importance in malaria parasite life cycle. In silico tools were used to predict the features of PfCoSP and to identify its homologues in bacteria, plants, humans, and other Plasmodium species. Modelled structures of PfCoSP and its homologues in Plasmodium species were compared with human cold shock protein ‘YBOX-1’ (Y-box binding protein 1) that provide important insights into their functioning. PfCoSP model was subjected to docking with B-form DNA and RNA to reveal a number of residues crucial for their interaction. Transcriptome analysis and motifs identified in PfCoSP implicate its role in controlling gene expression at gametocyte, ookinete and asexual blood stages of malaria parasite. Overall, this review emphasizes the functional diversity of the cold shock protein family by discussing their known roles in gene expression regulation, cold acclimation, developmental processes like flowering transition, and flower and seed development, and probable function in gametocytogenesis in case of malaria parasite. This enables readers to view the cold shock protein family comprehensively.

【 授权许可】

CC BY