Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas

BMC Medical Genetics

Bin Huang¹  Xia Jiang¹  Song Wu¹  Hongyan Lu¹  Guiping Yu¹  Hongbao Cao²  Xianping Meng³ 

[1] Department of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of Southeast University Medical College, 214400, Jiangyin, Jiangsu, China;Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, 030001, Taiyuan, Shanxi Province, China;Department of Genomics Research, RD Solutions, Elsevier Inc, 20852, Rockville, MD, USA;Department of Radiology, Jiangyin People’s Hospital, 214400, Jiangyin, Jiangsu Province, China;

关键词: Hyperkalemia;    Lung squamous cell carcinomas;    Mega-analysis;    Pathway analysis;    Multiple linear regression analysis;   

DOI  :  10.1186/s12881-020-01099-7

来源: Springer

【 摘 要 】

BackgroundPrevious studies indicated a strong association between hyperkalemia and lung squamous cell carcinomas (LSCC). However, the underlying mechanism is not fully understood so far.MethodsLiterature-based data mining was conducted to identify genes, molecule, and cell processes linked to both hyperkalemia and LSCC. Pathway analysis was performed to explore the interactive network, common-target network, and common-regulator network for both disorders. Then, a mega-analysis using 11 independent LSCC RNA expression datasets (358 LSCCs and 278 healthy controls) was performed to test the hypothesis that genes influencing hyperkalemia may also play roles in LSCC.ResultsThere was a significant overlap between the genes implicated with both diseases (20 genes, p-value = 4.98e-15), which counts for 16% of all hyperkalemia genes (125 genes). Network analysis identified 12 molecules as common targets for hyperkalemia and LSCC, and 19 molecules as common regulators. Moreover, 19 molecules were identified within an interactive network, through which hyperkalemia and LSCC could exert influence on each other. In addition, meta-analysis identified one hyperkalemia promoter, SPP1, as a novel contributor for LSCC (LFC = 2.64; p-value = 2.81e-6). MLR analysis suggests geographical region as an influential factor for the expression levels of SPP1 in LSCC patients (p value = 0.036, 0.054).ConclusionOur results showed that there was a common molecular basis for the pathology of both hyperkalemia and LSCC, and that genes promoting hyperkalemia might also play roles in the development of LSCC. However, this study did not suggest hypercalcemia as a casual factor for LSCC.

【 授权许可】

CC BY