Effects of alkaloids on peripheral neuropathic pain: a review

Chinese Medicine

Hanxiang Ma¹  Chunhao Zhu²  Miaomiao Tian²  Ning Liu³  Jiamei Yang³  Xiaobing Lan³  Jianqiang Yu⁴  Jianguo Niu⁵  Lin Ma⁵ 

[1] Department of Anesthesiology, General Hospital of Ningxia Medical University, No. 804 Shengli Street, 750004, Yinchuan, Ningxia Hui Autonomous Region, Ningxia, China;Department of Pharmacology, College of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, 750004, Yinchuan, Ningxia, China;Department of Pharmacology, College of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, 750004, Yinchuan, Ningxia, China;Ningxia Collaborative Innovation Center of Regional Characteristic Traditional Chinese Medicine, Ningxia Medical University, No. 692 Shengli Street, 750004, Yinchuan, Ningxia, China;Department of Pharmacology, College of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, 750004, Yinchuan, Ningxia, China;Ningxia Collaborative Innovation Center of Regional Characteristic Traditional Chinese Medicine, Ningxia Medical University, No. 692 Shengli Street, 750004, Yinchuan, Ningxia, China;Ningxia Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Ningxia Medical University, No. 1160 Shengli Street, 750004, Yinchuan, Ningxia, China;Ningxia Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Ningxia Medical University, No. 1160 Shengli Street, 750004, Yinchuan, Ningxia, China;

关键词: Chinese herbal medicines;    Alkaloids;    Peripheral neuropathic pain;    Analgesia;   

DOI  :  10.1186/s13020-020-00387-x

来源: Springer

【 摘 要 】

Neuropathic pain is a debilitating pathological pain condition with a great therapeutic challenge in clinical practice. Currently used analgesics produce deleterious side effects. Therefore, it is necessary to investigate alternative medicines for neuropathic pain. Chinese herbal medicines have been widely used in treating intractable pain. Compelling evidence revealed that the bioactive alkaloids of Chinese herbal medicines stand out in developing novel drugs for neuropathic pain due to multiple targets and satisfactory efficacy. In this review, we summarize the recent progress in the research of analgesic effects of 20 alkaloids components for peripheral neuropathic pain and highlight the potential underlying molecular mechanisms. We also point out the opportunities and challenges of the current studies and shed light on further in-depth pharmacological and toxicological studies of these bioactive alkaloids. In conclusion, the alkaloids hold broad prospects and have the potentials to be novel drugs for treating neuropathic pain. This review provides a theoretical basis for further applying some alkaloids in clinical trials and developing new drugs of neuropathic pain.

【 授权许可】

CC BY