A retrospective study of sepsis-associated encephalopathy: epidemiology, clinical features and adverse outcomes

BMC Emergency Medicine

Mengyuan Diao¹  Guangyong Jin¹  Wei Hu¹  Jiayi Chen¹  Shaosong Xi¹  Ying Zhu¹  Xiaobei Shi² 

[1] Department of Critical Care Medicine, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, No.261, Huansha Road, 310006, Zhejiang, Hangzhou, China;Department of Radiology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou, China;

关键词: Sepsis;    Sepsis-associated encephalopathy;    Retrospective study;   

DOI  :  10.1186/s12873-020-00374-3

来源: Springer

【 摘 要 】

BackgroundSepsis-associated encephalopathy (SAE) is a common complication of sepsis that may result in worse outcomes. This study was designed to determine the epidemiology, clinical features, and risk factors of SAE.MethodsThis was a retrospective study of all patients with sepsis who were admitted to the Critical Care Medicine Department of Hangzhou First People’s Hospital Affiliated with Zhejiang University School of Medicine from January 2015 to December 2019.ResultsA total of 291 sepsis patients were screened, and 127 (43.6%) were diagnosed with SAE. There were significant differences in median age, proportion of underlying diseases such as hypertension, Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, gastrointestinal infections, detection rate of Enterococcus, and 28-day mortality between the SAE and non-SAE groups. Both the SOFA score and APACHE II score were independent risk factors for SAE in patients with sepsis. All 127 SAE patients were divided into survival and non-survival groups. The age, SOFA score, and APACHE II score were independently associated with 28-day mortality in SAE patients.ConclusionIn the present retrospective study, nearly half of patients with sepsis developed SAE, which was closely related to poor outcomes. Both the SOFA score and APACHE II score were independent risk factors for predicting the occurrence and adverse outcome of SAE.

【 授权许可】

CC BY