Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus

eLife

Bryan Higashikubo¹  Andrew H Chang²  Irene Lew²  Agnieszka Ciesielska²  Frances S Cho³  Alexandra Clemente-Perez³  Jeanne T Paz³  Mahmood S Hoseini⁴  Michael P Stryker⁵ 

[1] Gladstone Institute of Neurological Disease, San Francisco, United States;Gladstone Institute of Neurological Disease, San Francisco, United States;University of California, San Francisco, Department of Neurology, San Francisco, United States;Gladstone Institute of Neurological Disease, San Francisco, United States;University of California, San Francisco, Neurosciences Graduate Program, San Francisco, United States;University of California, San Francisco, Department of Neurology, San Francisco, United States;Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, United States;University of California, San Francisco, Department of Physiology, San Francisco, United States;University of California, San Francisco, Department of Physiology, San Francisco, United States;University of California, San Francisco, Neurosciences Graduate Program, San Francisco, United States;Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, United States;

关键词: nucleus reticularis thalami;    gamma oscillations;    thalamocortical visual circuits;    visual cortex;    information transmission;    optogenetics;    Mouse;   

DOI  :  10.7554/eLife.61437

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Visual perception in natural environments depends on the ability to focus on salient stimuli while ignoring distractions. This kind of selective visual attention is associated with gamma activity in the visual cortex. While the nucleus reticularis thalami (nRT) has been implicated in selective attention, its role in modulating gamma activity in the visual cortex remains unknown. Here, we show that somatostatin- (SST) but not parvalbumin-expressing (PV) neurons in the visual sector of the nRT preferentially project to the dorsal lateral geniculate nucleus (dLGN), and modulate visual information transmission and gamma activity in primary visual cortex (V1). These findings pinpoint the SST neurons in nRT as powerful modulators of the visual information encoding accuracy in V1 and represent a novel circuit through which the nRT can influence representation of visual information.

【 授权许可】

CC BY