Kidney function and other factors and their association with falls

BMC Geriatrics

Agnieszka Guligowska¹  Tomasz Kostka¹  Francesco Mattace-Raso²  Lisanne Tap²  Ellen Freiberger³  Sabine Britting³  Robert Kob³  Regina Roller-Wirnsberger⁴  Axel C. Carlsson⁵  Johan Ärnlöv⁶  Rada Artzi-Medvedik⁷  Itshak Melzer⁸  Gerhard Wirnsberger⁹  Sara Lainez Martinez^1,10  Pedro Gil^1,10  Rafael Moreno-Gonzalez^1,11  Francesc Formiga^1,11  Andrea Corsonello^1,12  Fabrizia Lattanzio^1,12  Paolo Fabbietti^1,13 

[1] Department of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, Lodz, Poland;Department of Internal Medicine, Section of Geriatric Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands;Department of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;Department of Internal Medicine-Geriatrics, Medical University of Graz, Graz, Austria;Department of Medical Sciences, Uppsala University, Uppsala, Sweden;Division of Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;Department of Medical Sciences, Uppsala University, Uppsala, Sweden;Division of Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;School of Health and Social Studies, Dalarna University, Falun, Sweden;Department of Nursing, Recanati School for Community Health Professions at the faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel;Department of Physical Therapy, Recanati School for Community Health Professions at the faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel;Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria;Geriatric Department, Hospital Clínico San Carlos, Martín Lagos S/N, 28040, Madrid, Spain;Geriatric Unit, Internal Medicine Department, Bellvitge University Hospital – IDIBELL – L’Hospitalet de Llobregat, Barcelona, Spain;Italian National Research Center on Aging (IRCCS INRCA), Fermo and Cosenza, Ancona, Italy;Italian National Research Center on Aging (IRCCS INRCA), Fermo and Cosenza, Ancona, Italy;Laboratory of Geriatric Pharmacoepidemiology and Biostatistics, IRCCS INRCA, Via S. Margherita 5, 60124, Ancona, Italy;

关键词: Kidney function;    Older people;    Falls;    Injurious falls;    Fear of falling;    Urinary incontinence;   

DOI  :  10.1186/s12877-020-01698-2

来源: Springer

【 摘 要 】

BackgroundReduced kidney function has become a major public health concern, especially among older people, as Chronic Kidney Disease (CKD) is associated with increased risk of end stage renal disease and mortality. Falls are a serious negative health outcome in older persons with one third of people aged 65 years experiencing a fall per year and increasing fall rates with increasing age. The impact of CKD on falls in older community-dwelling persons is not well investigated. Additionally, lower urinary tract symptoms (LUTS) may also increase the risk of falls. Therefore, our aim was to investigate the impact of CKD and LUTS on falls as well as on injurious falls.MethodsThe SCOPE study is an observational, multinational, multicenter, prospective cohort study involving community-dwelling older persons aged 75 years and more recruited from August 2016 to March 2018 in seven European countries. The main outcomes of the present study were any falls and any injurious falls during the 12 months before enrolment. The cross-sectional association of estimated glomerular filtration rate (eGFR) and LUTS with study outcomes was investigated by logistic regression analysis adjusted for baseline characteristics of enrolled subjects.ResultsOur series consisted of 2256 SCOPE participants (median age = 79.5 years, 55.7% female). Of them, 746 participants experienced a fall and 484 reported an injurious fall in the 12 months prior to baseline assessment. CKD was not significantly associated with falls (OR = 0.95, 95%CI = 0.79–1.14 for eGFR< 60; OR = 1.02, 95%CI = 0.81–1.28 for eGFR< 45; OR = 1.08, 95%CI = 0.74–1.57 for eGFR< 30) or injurious falls (OR = 0.91, 95%CI = 0.67–1.24 for eGFR< 60; OR = 0.93, 95%CI = 0.63–1.37 for eGFR< 45; OR = 1.19, 95%CI = 0.62–2.29 for eGFR< 30). LUTS were found significantly associated with both falls (OR = 1.56, 95%CI = 1.29–1.89) and injurious falls (OR = 1.58, 95%CI = 1.14–2.19), and such associations were confirmed in all multivariable models.ConclusionsCross-sectional data suggest that CKD may not be associated with history of falls or injurious falls, whereas LUTS is significantly associated with the outcomes.Trial registrationThis study was registered on 25th February 2016 at clinicaltrials.gov (NCT02691546).

【 授权许可】

CC BY