Years of life lost due to premature death and their trends in people with malignant neoplasm of female genital organs in Shanghai, China during 1995–2018: a population based study

BMC Public Health

Yi Zhou¹  Xiaopan Li¹  Yichen Chen¹  Guifen Ma²  Yuan He³  Yan Du³  Yang Deng⁴  Xiaoyun Xu⁵  Zheng Luo⁵ 

[1] Center for Disease Control and Prevention, No. 3039 Zhangyang Rd., Pudong New Area, 200136, Shanghai, China;Fudan University Pudong Institute of Preventive Medicine, Pudong New Area, 200136, Shanghai, China;Department of Radiotherapy, Zhongshan Hospital, Fudan University, 200032, Shanghai, China;Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, 200011, Shanghai, China;School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 271016, Tai’an, Shandong, China;Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1500 Zhouyuan Rd., Pudong New Area, 201318, Shanghai, China;

关键词: Malignant neoplasm of female genital organs;    Mortality;    Years of life lost;    Trend analysis;    Decomposition method;   

DOI  :  10.1186/s12889-020-09593-6

来源: Springer

【 摘 要 】

BackgroundThe increasing aging population has been posing a significant challenge to disease burden in developing countries. In particular, the contribution of population aging to and long term changes of disease burden of malignant neoplasm of female genital organs (MNFGO) have not been quantitatively demonstrated.MethodsData were collected from the Shanghai Vital Statistics System of Pudong New Area (PNA). Crude mortality rate (CMR), age-standardized mortality rate by Segi’s world standard population (ASMRW), and years of life lost (YLL) of MNFGO as the underlying cause of death in age and pathology types from 1995 to 2018 were calculated. The joinpoint regression was used to estimate the trends of those rates by identifying the annual percent changes (APCs), and the decomposition method was used to calculate the increased rates and the contribution resulting from demographic and non-demographic factors.ResultsFrom 1995 to 2018, a total of 2869 MNFGO-specific deaths were reported in PNA, accounting for 0.64% of the total deaths. The CMR and ASMRW of MNFGO were 9.23/105 person-years and 4.80/105 person-years, respectively. Ovary cancer was the most common cause of MNFGO death, accounting for 43.9% (1260/2869) of all MNFGO death. Other common causes of MNFGO death included cervix uteri cancer, uterus unspecified cancer, and corpus uteri cancer. With the increase of age, the mortality rate of MNFGO in residents had shown an upward trend ([APC (95%CI) = 3.46 (2.74, 4.18), P < 0.001)] for each five-year age group from 0 to 4 to 85+ years. From 1995 to 2018, YLL of MNFGO in Shanghai PNA was 42,152.82 years, and the rate of YLL was 135.56 /105. The top three MNFGO types in YLLs were ovary cancer, cervix uteri cancer and uterus unspecified cancer. Demographic factors contributed significantly to the upward trends of CMR, ASMRW, and YLL rates of MNFGO.ConclusionWith aggravated population aging in Shanghai, MNFGO is and will continue to be a serious threat to women’s health. More precise and effective prevention strategies are needed to target high risk population, to achieve efficient health resource allocation and to improve women’s health in particular.

【 授权许可】

CC BY