Buprenorphine therapy in the setting of induced opioid withdrawal from oral naltrexone: a case report

Harm Reduction Journal

Vincent J. Calleo¹  Ross W. Sullivan¹  Laura M. Szczesniak² 

[1] Department of Emergency Medicine, Upstate Medical University, 750 E Adams St, 13210, Syracuse, NY, USA;Department of Pharmacology, Upstate Medical University, 750 E Adams St, 13210, Syracuse, NY, USA;

关键词: Buprenorphine;    Opioid use disorder;    Overdose;    Substance use treatment;    Precipitated withdrawal;    Naltrexone;   

DOI  :  10.1186/s12954-020-00417-9

来源: Springer

【 摘 要 】

BackgroundPatients with opioid use disorder (OUD) frequently present to the emergency department for acute treatment of overdose and withdrawal.Case presentationA 29-year-old male presented to the emergency room after intravenous heroin use followed by accidental ingestion of naltrexone. He was treated with buprenorphine with significant improvement in his Clinical Opioid Withdrawal Score, from moderately severe to mild withdrawal symptoms within a few hours.ConclusionBuprenorphine and minimal supportive care can be used to treat acute withdrawal precipitated by oral naltrexone in patients with OUD.

【 授权许可】

CC BY