Low-grade oncocytic tumour of kidney (CD117-negative, cytokeratin 7-positive)

Surgical and Experimental Pathology

Cláudio Galeno Ramalho de Andrade Melo¹  Isabela Soares Pimenta²  Daniel Abensur Athanazio³  Marcus Vinicius Nunes Xavier⁴ 

[1] Federal University of Bahia/ Campus Anísio Teixeira, Vitória da Conquista, Bahia, Brazil;Imagepat, Laboratory of Pathology. Avenida Jorge Teixeira, 29, Medical Center, Lojas 05 e 06, Candeias, 45028 - 050, Vitória da Conquista, BA, Brazil;Imagepat, Laboratory of Pathology. Avenida Jorge Teixeira, 29, Medical Center, Lojas 05 e 06, Candeias, 45028 - 050, Vitória da Conquista, BA, Brazil;Hospital Universitário Professor Edgard Santos / Federal University of Bahia, Salvador, Bahia, Brazil;Uroday Hospital, Vitória da Conquista, Bahia, Brazil;

关键词: Carcinoma;    Renal cell;    Kidney neoplasms;    Kidney;   

DOI  :  10.1186/s42047-020-00074-z

来源: Springer

【 摘 要 】

BackgroundThe term low-grade oncocytic tumour of kidney is an emerging entity describing CD117-negative and cytokeratin 7-positive indolent tumors with overlapping morphological features between oncocytic tumors.Case presentationWe present herein the case of a 77-year-old female with a 3.2-cm nodule in mid pole of the left kidney. The tumor was uniformly oncocytic with solid, compact nested and trabecular growth patterns. There was common areas of transition to central zones of stromal edema with marked tumor hypocellularity and growth in cords. Some of these areas had adjacent fresh hemorrhage. Immunohistochemistry showed strong and diffuse expression of cytokeratin 7 and negativity for cKIT/CD117.ConclusionThe proper use of this new diagnostic category avoids labeling such tumors as unclassified renal cell carcinoma – a broad category with different morphologic features and heterogenous prognosis.

【 授权许可】

CC BY