The ultimate preoperative C-reactive protein-to-albumin ratio is a prognostic factor for survival after pancreatic cancer resection

European Journal of Medical Research

Matthijs A. Kanters¹  Joost M. Klaase¹  Laura van Wijk¹  Guus W. de Klein²  Gijs A. Patijn² 

[1] Department of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, PO Box 30001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands;Department of Surgery, Isala, PO Box 10400, Dokter van Heesweg 2, 8000 GK, Zwolle, The Netherlands;

关键词: Albumin;    C-reactive protein;    Albumin;    CAR;    Modified Glasgow Prognostic Score;    Pancreatic cancer;    Survival;   

DOI  :  10.1186/s40001-020-00444-z

来源: Springer

【 摘 要 】

BackgroundEmerging evidence indicates that an elevated C-reactive protein-to-albumin ratio (CAR) may be associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Further evidence showing that this ratio has significant prognostic value could contribute to current prediction models and clinical decision-making.MethodsData were analysed of consecutive patients who underwent curative pancreatic resection between 2013 and 2018 and were histologically diagnosed with PDAC. We investigated the relation between the ultimate preoperative CAR and overall survival.ResultsA total of 163 patients were analysed. Median overall survival was 18 months (IQR 9–36). Multivariate analysis demonstrated that a higher CAR (HR 1.745, P = 0.004), a higher age (HR 1.062, P < 0.001), male sex (HR 1.977, P = 0.001), poor differentiation grade (HR 2.812, P < 0.001), and positive para-aortic lymph node(s) (HR 4.489, P < 0.001) were associated with a lower overall survival. Furthermore, a CAR ≥ 0.2 was associated with decreased overall survival (16 vs. 26 months, P = 0.003).ConclusionWe demonstrated that an ultimate preoperative elevated CAR is an independent indicator of decreased overall survival after resection for PDAC. The preoperative CAR may be of additional value to the current prediction models.

【 授权许可】

CC BY