Ultra-sensitive Nanoprobe Modified with Tumor Cell Membrane for UCL/MRI/PET Multimodality Precise Imaging of Triple-Negative Breast Cancer

Nano-Micro Letters

Mingyuan Gao¹  Xiao Zhang²  Hanyi Fang²  Xiaoli Lan²  Yongxue Zhang²  Qingyao Liu²  Yongkang Gai²  Mengting Li²  Lujie Yuan²  Min Ye²  Yi Hou³  Sheng Wang⁴ 

[1] Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, 215123, Suzhou, Jiangsu, People’s Republic of China;Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, People’s Republic of China;Hubei Province Key Laboratory of Molecular Imaging, 430022, Wuhan, People’s Republic of China;Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, 100190, Beijing, People’s Republic of China;School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People’s Republic of China;

关键词: Triple-negative breast cancer;    Molecular classification;    Multimodality imaging;    Cancer cell membranes;    Upconversion;   

DOI  :  10.1007/s40820-020-0396-4

来源: Springer

【 摘 要 】

tsA biomimetic nanoprobe was built with cancer cell membrane-coated and Gd3+-doped upconversion nanoparticles.The nanoprobe could be applied to in vivo UCL/MRI/PET multimodality precise imaging and successfully differentiated MDA-MB-231 tumor models through in vivo tri-modality imaging, which may be used for breast cancer molecular classification.

【 授权许可】

CC BY