Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip

BMC Musculoskeletal Disorders

Jesper Skovhus Thomsen¹  Andreas Wiggers Nielsen²  Ellen-Margrethe Hauge³  Rasmus Klose-Jensen³  Louise Brøndt Hartlev⁴  Kresten Krarup Keller⁵  Lene Warner Thorup Boel⁶  Mogens Laursen⁷ 

[1] Department of Biomedicine – Anatomy, Aarhus University, Aarhus, Denmark;Department of Rheumatology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 45, 8200, Aarhus, Denmark;Department of Rheumatology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 45, 8200, Aarhus, Denmark;Department of Clinical Medicine, Aarhus University, Aarhus, Denmark;Department of Rheumatology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 45, 8200, Aarhus, Denmark;Department of Clinical Medicine, Randers Regional Hospital, Randers, Denmark;Department of Rheumatology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 45, 8200, Aarhus, Denmark;Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark;Institute of Forensic Medicine, Aarhus University, Aarhus, Denmark;Orthopaedic Surgery Research Unit, Aalborg University Hospital, Aalborg, Denmark;

关键词: Osteoarthritis;    Femoral head;    Osteophytes;   

DOI  :  10.1186/s12891-020-03648-w

来源: Springer

【 摘 要 】

ObjectiveThe objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis (OA), and to compare these to that of a control group.DesignWe investigated femoral heads from 25 patients with OA following hip replacement surgery, and 25 femoral heads from a control group obtained post-mortem. The area and boundary length of the femoral head, marginal osteophytes, and subarticular osteophytes were determined with histomorphometry. Marginal osteophytes were defined histologically as bony projections at the peripheral margin of the femoral head, while subarticular osteophytes were defined as areas of bone that expanded from the normal curvature of the femoral head into the articular cartilage.ResultsThe prevalence of OA patients with marginal- and subarticular osteophytes were 100 and 84%, respectively. Whereas the prevalence of the participants in the control group with marginal- and subarticular osteophytes were 56 and 28%, respectively.The area and boundary length of marginal osteophytes was (median (Interquartile range)) 165.3mm2 (121.4–254.0) mm2 and 75.1 mm (50.8–99.3) mm for patients with OA compared to 0 mm2 (0–0.5) mm2 and 0 mm (0–0.5) mm for the control group (P <  0.001). For the subarticular osteophytes, the area and boundary length was 1.0 mm2 (0–4.4) mm2 and 1.4 mm (0–6.5) mm for patients with OA compared to 0 mm2 (0–0.5) mm2 and 0 mm (0–0.5) mm for the control group (P <  0.001).ConclusionAs expected, both marginal- and subarticular osteophytes at the femoral head, were more frequent and larger in patients with OA than in the control group. However, in the control group, subarticular osteophytes were more prevalent than expected from the minor osteophytic changes at the femoral head margin, which may suggest that subarticular osteophytes are an early degenerative phenomenon that ultimately might develop into clinical osteoarthritis.

【 授权许可】

CC BY