Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report

Journal of Medical Case Reports

Samuel A. Kareff¹  Rebecca Krochmal²  Jonathan W. Lischalk³  Chul Kim⁴ 

[1] Department of Graduate Medical Education, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, 20007, Washington, DC, USA;Department of Pulmonology and Critical Care Medicine, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, 20007, Washington, DC, USA;Department of Radiation Medicine, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, 20007, Washington, DC, USA;Georgetown Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, 20007, Washington, DC, USA;

关键词: Abscopal effect;    Neuroendocrine tumor;    Pulmonary carcinoid;   

DOI  :  10.1186/s13256-020-02512-8

来源: Springer

【 摘 要 】

BackgroundThe abscopal effect was described as early as the 1950s, when untreated tumors demonstrated a response after radiation therapy was delivered to an untreated, distant site. The mechanisms underlying this global response to otherwise localized therapy remain unknown, though there is increasing evidence that increased antigen expression following ablative radiotherapy may play a role.Case presentationWe report a case of a 69-year-old African American woman with a history of metastatic typical pulmonary carcinoid with multiple lung nodules who had a significant decrease in size of an untreated left upper lobe nodule after stereotactic body radiation therapy to an oligoprogressive left lower lobe lesion.ConclusionsTo our knowledge, this report describes the first case of an abscopal effect in a typical pulmonary carcinoid. Further research is needed regarding the mechanisms responsible for this finding and the role of combining radiation therapy and cancer immunotherapy in patients with pulmonary carcinoid tumors.

【 授权许可】

CC BY