Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

BMC Cancer

Livia Giordano¹  Niccolò Gallio²  Chiara Benedetto²  Leonardo Micheletti²  Stefano Cosma²  Federica Bevilacqua²  Carola Libero²  Mario Preti²  Irene Sobrato³  Stefano Rosso³  Paola Busso³ 

[1] Cancer Prevention Center of Piedmont, Torino, Italy;Department of Surgical Sciences University of Torino, Via Ventimiglia 3, 10126, Torino, Italy;Piedmont Cancer Registry – CPO, Torino, Italy;

关键词: HPV-related cancers;    Anogenital area;    Anal cancer;    Vaginal cancer;    Vulvar cancer;    Multiple subsequent cancers;   

DOI  :  10.1186/s12885-020-07452-6

来源: Springer

【 摘 要 】

BackgroundThe aim was to estimate the risk of subsequent extra-cervical Human Papillomavirus (HPV) related cancer in patients surgically treated for high grade cervical intraepithelial neoplasia (CIN 2–3). This is the first study in Italy investigating the occurrence of extra-cervical tumors in this cohort of patients.Methods3184 patients surgically treated for CIN2–3 since 1992 at the Department of Surgical Sciences of University of Torino were considered. The risk of HPV-related cancer was calculated as Standardized Incidence Ratio (SIR), using as expected values tumour age specific incidence of resident population.Results173 second primary cancer (SCPs) were identified. SIR to develop cancer after treatment for CIN2–3 was 2.2 (CI 95% 1.89–2.50). Among these occurrences, 10 are in HPV related sites: 1 anus (SIR = 1.8; 0.04–10.0), 3 vagina (SIR = 12.4; 2.56–36.3), 1 vulva (SIR = 1.7; 0.04–9.59), 5 oropharynx (SIR = 8.5; 2.76–19.8).Significant risk has been also recorded for pulmonary (SIR = 3.1; 0.70–5.27) and bladder (SIR = 4.05; 1.10–10.56), with smoking as possible cofactor. We also found increased risk for breast (SIR = 2.4; 2.07–2.84) and ovarian cancers (SIR = 2.1; 1.13–3.49), probably due to an higher adherence to spontaneous and programmed screening programs.ConclusionsOur study supports the hypothesis of an increased risk of HPV-related tumours for CIN treated patients, mostly for CIN3. It is conceivable the need of early diagnosis for these cancers in this higher-risk populations.

【 授权许可】

CC BY