Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy

Nano-Micro Letters

Xiongfeng Cao¹  Guangming Lu²  Ying Tian²  Zhaogang Teng³  Wanhua Liu⁴  Xin Peng⁴  Mengru Wang⁴  Jun Tao⁵  Kun Chen⁵  Lei Bao⁶ 

[1] Affiliated Hospital of Jiangsu University, Jiangsu University, 212001, Zhenjiang, People’s Republic of China;Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, 210002, Nanjing, People’s Republic of China;Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, 210002, Nanjing, People’s Republic of China;Key Laboratory for Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, 210023, Nanjing, People’s Republic of China;Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 210009, Nanjing, Jiangsu, People’s Republic of China;Key Laboratory for Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, 210023, Nanjing, People’s Republic of China;Soft Matter and Interface Group, School of Engineering, RMIT University, 3000, Melbourne, VIC, Australia;

关键词: Mesoporous organosilica;    Soft nanoplatform;    Long circulation;    Tumor accumulation;    Tumor penetration;   

DOI  :  10.1007/s40820-020-00465-7

来源: Springer

【 摘 要 】

tsSoft mesoporous organosilica nanoplatforms modified with hyaluronic acid and cyanine 5.5 are constructed.Therapeutic efficacy of the soft nanoplatforms on tumor is higher both in vitro and in vivo after loading photosensitizer chlorin e6 compared to that of stiff counterparts.

【 授权许可】

CC BY