A multi-center, randomized controlled trial by the Integrative Management in Japan for Epidemic Disease (IMJEDI study-RCT) on the use of Kampo medicine, kakkonto with shosaikotokakikyosekko, in mild-to-moderate COVID-19 patients for symptomatic relief and prevention of severe stage: a structured summary of a study protocol for a randomized controlled trial

Trials

Takashi Ito¹  Tetsuhiro Yoshino²  Airi Takagi³  Mosaburo Kainuma⁴  Tomoaki Ishigami⁵  Kotaro Nochioka⁶  Hajime Nakae⁷  Takao Namiki⁸  Ryutaro Arita⁹  Shin Takayama^1,10  Tadashi Ishii^1,10  Masaru Mimura^1,11  Seiichi Kobayashi^1,12  Koichiro Tanaka^1,13  Takuhiro Yamaguchi^1,14 

[1] Akashi Clinic Kanda, 3-8, Kandaogawa-machi, Chiyoda-ku, 101-0052, Tokyo, Japan;Center for Kampo Medicine, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan;Clinical Research Data Center, Tohoku University Hospital, 1-1, Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan;Community Medicine Education Unit, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan;Department of Cardiology, Yokohama City University Hospital, 3-9, Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan;Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan;Department of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine, 1-1-1, Hondo, 010-8543, Akita, Japan;Department of Japanese-Oriental (Kampo) Medicine, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, 260-8670, Chiba, Japan;Department of Kampo Medicine, Tohoku University Hospital, 1-1, Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan;Department of Education and Support for Regional Medicine, Tohoku University Hospital, 1-1, Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan;Department of Kampo Medicine, Tohoku University Hospital, 1-1, Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan;Department of Education and Support for Regional Medicine, Tohoku University Hospital, 1-1, Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan;Department of Kampo and Integrative Medicine, Tohoku University Graduate School of Medicine, 1-2, Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan;Department of Neuropsychiatry, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan;Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Nishimichishita-71, Hebita, 986-8522, Ishinomaki, Japan;Department of Traditional Medicine, Faculty of Medicine, Toho University, 6-11-1, Omori-nishi, Ota-ku, 143-8541, Tokyo, Japan;Division of Biostatistics, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan;

关键词: COVID-19;    Randomized controlled trial;    Protocol;    Kampo medicines;    Symptom relief;    Prevention for severe stage;   

DOI  :  10.1186/s13063-020-04746-9

来源: Springer

【 授权许可】

CC BY