Associated factors of REM sleep without atonia in younger (≤ 50 years) hospitalized psychiatric patients

BMC Psychiatry

Jana Kopřivová¹  Jiřina Kosová¹  Eva Miletínová¹  Monika Kliková¹  Tomáš Novák¹  Martin Bareš¹  Jitka Bušková¹  Pavla Stopková¹ 

[1] Department of Sleep Medicine, National Institute of Mental Health, Topolová 748, 250 67, Klecany, Czech Republic;Third Faculty of Medicine, Charles University, Prague, Czech Republic;

关键词: REM sleep without atonia;    REM sleep behaviour disorder;    Psychiatric patients;    Antidepressants;    Antipsychotics;    Anxiety;    Depression;   

DOI  :  10.1186/s12888-020-02879-4

来源: Springer

【 摘 要 】

BackgroundIsolated REM sleep without atonia (RSWA) as a main polysomnograhic feature of REM sleep behaviour disorder (RBD) is thought to be a prodromal or subclinical state of the disease. RSWA/RBD occurence in psychiatric population is much more frequent than in general population but its associated factors are still not known.MethodsWe invited 88 psychiatry in-patients to undervent video-polysomnography. The visual scoring was focused on RSWA in submentales and flexores digitales superficiales muscles. This parametr was subsequently correlated mainly with age/gender, their medication and mental status.ResultsThe RWSA was mostly still in normal range despite the fact, that selected psychiatry patients (≤ 50 years) were taking several classes of psychoactive medication. 3,6% had convincingly RBD, although 35.7% reported rare lifetime occurence of dream-enacting behaviour and 62.8% sporadic nightmares. We found correlation between RSWA and SNRI medication class (p = 0.015), specifically venlafaxine (p = 0.029) as well as quetiapine (p = 0.030). Another significant associated factors were current anxiety (p < 0.001) and depressive symptoms (p = 0.05), but we found no relation between RSWA and given diagnosis.ConlucionsIsolated RSWA in younger psychiatry patients might be a result of multiple factors, including medication and current mental status but these factors are in most cases not sufficient to manifest RBD.

【 授权许可】

CC BY